protein 1,687 words KG: LAPTM4APROTEIN 2026-03-29
kind:proteinsection:proteinsstate:publisheddisease:alzheimers-diseasedisease:parkinsons-diseasepathway:lysosomal-functionpathway:autophagy
Contents

LAPTM4A Protein — Lysosomal-Associated Transmembrane Protein 4 Alpha

🔬 Protein Info
Gene SymbolLAPTM4A
Full NameLysosomal Associated Transmembrane Protein 4 Alpha
AliasesLAPTM4APROTEIN
Chromosome2p23.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious tissues including the brain, where it supports neuronal survival and function
Subcellular LocalizationPrimarily lysosomal membranes
Amino Acids224 aa
PathwaysmTOR, mtor
UniProt ID[Q9Y3Q5](https://www.uniprot.org/uniprot/Q9Y3Q5)
Ensembl IDENSG00000137714
GeneCardsLAPTM4A
Human Protein AtlasLAPTM4A
Associated Diseasesneurodegeneration
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Lysosomal Calcium Channel Modulation Therapy
Score: 0.49
Lysosomal Enzyme Trafficking Correction
Score: 0.49

Related Analyses (11)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in