Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LDLRECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LDLRECEPTOR |
| Full Name | LDL Receptor |
| Protein Type | Protein |
| Function | is a cell surface receptor essential for cholesterol homeostasis. |
| Primary Expression | epithelial cells |
| Amino Acids | 40 aa |
| UniProt ID | Search UniProt |
| GeneCards | LDLRECEPTOR |
| Human Protein Atlas | LDLRECEPTOR |
| Ligand-binding repeats (LA repeats) | Seven repeats of approximately 40 amino acids each, containing negatively charged amino acids that interact with positively charged residues on apolipoproteins |
| EGF-like domains | Three epidermal growth factor precursor homology domains |
| O-linked sugar domain | A region with O-linked glycosylation |
| Transmembrane domain | Single pass transmembrane helix (22 amino acids) |
| Cytoplasmic tail | Contains an NPXY internalization signal and a di-leucine sorting motif |
| LDLR | Classic LDL receptor |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LDLRECEPTOR["LDLRECEPTOR"]
neurodegeneration["neurodegeneration"]
LDLRECEPTOR -->|"implicated_in"| neurodegeneration
style LDLRECEPTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LDLRECEPTOR in their description or question text
No additional research found