gene

LFNG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LFNG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for LFNG Gene - Lunatic Fringe

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🧬 Gene Info

Gene Symbol	LFNG
Aliases	Page for LFNG Gene
Chromosome	7q32
Protein Type	Transferase
Function	Lunatic Fringe (LFNG) is a member of the Fringe family of glycosyltransferases that catalyze the addition of N-acetylglucosamine (GlcNAc) to O-fucose residues on Notch receptors.
Primary Expression	hippocampus (dentate gyrus), subventricular zone, and cerebellar Purkinje cells
Pathways	Notch, Notch signaling, NOTCH
Ensembl ID	ENSG00000166323
GeneCards	LFNG
Human Protein Atlas	LFNG
Notch Receptors and Ligands	Primary substrates of LFNG glycosylation
POFUT1	Upstream O-fucosyltransferase required for LFNG substrate recognition
RFNG and MFNG	Related fr
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    LFNG["LFNG"]
    neurodegeneration["neurodegeneration"]
    LFNG -->|"implicated_in"| neurodegeneration
    style LFNG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity