Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LIG1 |
| Aliases | CDC9, Ligase I |
| Chromosome | 19q13.3 |
| Function | DNA Ligase 1 is specifically involved in |
| Molecular Weight | 102 kDa |
| GeneCards | LIG1 |
| Human Protein Atlas | LIG1 |
| Okazaki Fragment Ligation | During DNA replication, LIG1 seals the nicks between Okazaki fragments on the lagging strand, ensuring continuous DNA synthesis. |
| Nucleotide Excision Repair (NER) | LIG1 contributes to repair of UV-induced DNA lesions and other bulky adducts. |
| DNA Replication Fidelity | By sealing nicks during replication, LIG1 maintains genomic stability. |
| Parkinson's Disease (PD) | Oxidative stress in dopaminergic neurons can cause DNA damage. LIG1 deficiency may impair repair mechanisms, accelerating neurodegeneration in the substantia nigra. |
| Amyotrophic Lateral Sclerosis (ALS) | Motor neurons exhibit increased sensitivity to DNA damage. LIG1 polymorphisms may modify disease progression. |
| Aging | Age-related decline in LIG1 activity correlates with accumulated DNA damage in neurons. |
| DNA Repair Enhancement | Small molecules that enhance LIG1 activity or stability may protect neurons from DNA damage-induced death. |
| Gene Therapy | Viral vectors delivering functional LIG1 could potentially restore DNA repair capacity in affected neurons. |
| Associated Diseases | neurodegeneration |
| Interactions | MLH1, MSH2, MSH3, MSH6, PMS2 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["LIG1"]
N1["MLH1"]
N0 -->|"interacts with"| N1
N2["MSH2"]
N0 -->|"interacts with"| N2
N3["MSH3"]
N0 -->|"interacts with"| N3
N4["MSH6"]
N0 -->|"interacts with"| N4
N5["PMS2"]
N0 -->|"interacts with"| N5
N6["neurodegeneration"]
N0 -->|"implicated in"| N6
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class N0 gene
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class N5 gene| Source | Relation | Type | Str |
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| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||