protein

MSH6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MSH6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

0Analyses

39Outgoing

32Incoming

Summary

MSH6 is a protein involved in neurodegeneration research. Key relationships include: expressed in, regulates, associated with. Associated with Aging, Als, Cancer. Connected to 57 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	MSH6
Full Name	MutS Homolog 6
Aliases	Page for MSH6 Protein
Function	MSH6 forms a heterodimer with MSH2 (MutSα):
Molecular Weight	160 kDa
Pathways	Apoptosis, Dna Repair, Epigenetic, Mtor
Ensembl ID	ENSG00000182162
GeneCards	MSH6
Human Protein Atlas	MSH6
Neuronal DNA repair	Active base excision repair and MMR in post-mitotic neurons
Somatic mutation prevention	Prevents accumulation of mutations in long-lived neurons
Transcriptional fidelity	Maintains accuracy of gene expression
Associated Diseases	Als, Cancer, Colorectal Cancer, Gastric Cancer, glioblastoma
Interactions	CDK1, PMS2, LIG1, MLH1, MSH2, MSH3
KG Connections	71 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MSH6["<b>MSH6</b>"]
    Cancer{"Cancer"}
    MSH6 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    MSH6 -->|"expressed in"| Tumor
    Ms{"Ms"}
    MSH6 -->|"expressed in"| Ms
    Aging{"Aging"}
    MSH6 -->|"regulates"| Aging
    MSH6 -->|"activates"| Ms
    MSH6 -->|"regulates"| Cancer
    MSH6 -->|"regulates"| Tumor
    GENES["GENES"]
    MSH6 -->|"expressed in"| GENES
    DNA["DNA"]
    MSH6 -->|"expressed in"| DNA
    ATRX["ATRX"]
    MSH6 -->|"expressed in"| ATRX
    AKT["AKT"]
    MSH6 -->|"expressed in"| AKT
    TP53["TP53"]
    MSH6 -->|"expressed in"| TP53
    MSH2["MSH2"]
    MSH2 -->|"expressed in"| MSH6
    PI3K["PI3K"]
    PI3K -->|"expressed in"| MSH6
    RB1["RB1"]
    RB1 -->|"expressed in"| MSH6
    TP53 -->|"expressed in"| MSH6
    GENES -->|"expressed in"| MSH6
    ATRX -->|"expressed in"| MSH6
    AKT -->|"expressed in"| MSH6
    DNA -->|"expressed in"| MSH6
    MLH1["MLH1"]
    MLH1 -->|"expressed in"| MSH6
    CANCER["CANCER"]
    CANCER -->|"expressed in"| MSH6
    style MSH6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Aging	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Gastric Cancer	associated_with	disease	0.65
ATRX	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
MLH1	expressed_in	gene	0.60
CDK1	activates	gene	0.60
PI3K	expressed_in	gene	0.60
HDAC2	regulates	gene	0.60
PMS2	causes	gene	0.60
PMS2	interacts_with	gene	0.60
PMS2	associated_with	gene	0.60
TDP43	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
Dna Methylation	expressed_in	pathway	0.60
Akt	expressed_in	pathway	0.60
Pi3K	expressed_in	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
CANCER	regulates	gene	0.60
MTORC1	regulates	gene	0.60
Mtor	regulates	pathway	0.60
Dna Repair	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Microrna	associated_with	pathway	0.60
Mismatch Repair	associated_with	pathway	0.60
Epigenetic	regulates	pathway	0.60
glioblastoma	expressed_in	disease	0.60
glioblastoma	implicated_in	disease	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (32)

Source	Relation	Type	Str
MSH2	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
RB1	expressed_in	gene	0.60
TP53	expressed_in	gene	0.60
ATRX	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
MLH1	expressed_in	gene	0.60
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	regulates	gene	0.60
ARID1A	regulates	gene	0.60
ACVR2A	regulates	gene	0.60
MRE11	associated_with	gene	0.60
MSH2	causes	gene	0.60
MSH3	regulates	gene	0.60
MLH1	causes	gene	0.60
LIG1	interacts_with	gene	0.60
MLH1	interacts_with	gene	0.60
MSH2	interacts_with	gene	0.60
MSH3	interacts_with	gene	0.60
GBM	expressed_in	gene	0.60
GBM	implicated_in	gene	0.60
MLH1	associated_with	gene	0.60
MSH2	associated_with	gene	0.60
MSH3	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	associated_with	gene	0.60
GENES	causes	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MSH6

Understanding Entity Pages

Summary

Wiki Pages (18)

MSH6 — MutS Homolog 6

Huntington's Disease Somatic CAG Expansion and DNA Repair

POLD1

PMS2 — DNA Mismatch Repair Protein PMS2

POLD1 Protein

POLD4 Protein

DNA Damage and Repair Dysfunction in PSP

DNA Repair Mechanisms in Neurodegeneration

DNA Damage-Accumulating Neurons in Neurodegeneration

MSH2 — MutS Homolog 2

DNA Damage Response and Repair in Neurodegeneration

MSH2 Protein - MutS Homolog 2

MLH1 Gene

LIG1

MSH6 Protein - MutS Homolog 6

MSH3 Gene