MLH1

Understanding Entity Pages

This page aggregates everything SciDEX knows about MLH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MLH1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, activates. Associated with Als, Cancer, Carcinoma. Connected to 88 entities in the SciDEX knowledge graph.

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graph TD
    MLH1["<b>MLH1</b>"]
    Cancer{"Cancer"}
    MLH1 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    MLH1 -->|"expressed in"| Tumor
    Ms{"Ms"}
    MLH1 -->|"expressed in"| Ms
    Huntington{"Huntington"}
    MLH1 -->|"activates"| Huntington
    MLH1 -->|"inhibits"| Ms
    MLH1 -->|"inhibits"| Cancer
    MLH1 -->|"activates"| Tumor
    Als{"Als"}
    MLH1 -->|"therapeutic target"| Als
    MLH1 -->|"therapeutic target"| Ms
    MLH1 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    MLH1 -->|"therapeutic target"| Carcinoma
    Dna_Methylation(["Dna Methylation"])
    MLH1 -->|"expressed in"| Dna_Methylation
    MSH2["MSH2"]
    MSH2 -->|"expressed in"| MLH1
    PI3K["PI3K"]
    PI3K -->|"expressed in"| MLH1
    RB1["RB1"]
    RB1 -->|"expressed in"| MLH1
    MSH6["MSH6"]
    MSH6 -->|"expressed in"| MLH1
    GENES["GENES"]
    GENES -->|"expressed in"| MLH1
    DNA["DNA"]
    DNA -->|"expressed in"| MLH1
    ATRX["ATRX"]
    ATRX -->|"expressed in"| MLH1
    AKT["AKT"]
    AKT -->|"expressed in"| MLH1
    TP53["TP53"]
    TP53 -->|"expressed in"| MLH1
    STING["STING"]
    STING -->|"activates"| MLH1
    DNA -->|"activates"| MLH1
    CGAS_STING["CGAS-STING"]
    CGAS_STING -->|"activates"| MLH1
    style MLH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0