| Gene Symbol | LIG1 |
| Aliases | CDC9, Ligase I |
| Chromosome | 19q13.3 |
| Function | DNA Ligase 1 is specifically involved in |
| Molecular Weight | 102 kDa |
| GeneCards | LIG1 |
| Human Protein Atlas | LIG1 |
| Okazaki Fragment Ligation | During DNA replication, LIG1 seals the nicks between Okazaki fragments on the lagging strand, ensuring continuous DNA synthesis. |
| Nucleotide Excision Repair (NER) | LIG1 contributes to repair of UV-induced DNA lesions and other bulky adducts. |
| DNA Replication Fidelity | By sealing nicks during replication, LIG1 maintains genomic stability. |
| Parkinson's Disease (PD) | Oxidative stress in dopaminergic neurons can cause DNA damage. LIG1 deficiency may impair repair mechanisms, accelerating neurodegeneration in the substantia nigra. |
| Amyotrophic Lateral Sclerosis (ALS) | Motor neurons exhibit increased sensitivity to DNA damage. LIG1 polymorphisms may modify disease progression. |
| Aging | Age-related decline in LIG1 activity correlates with accumulated DNA damage in neurons. |
| DNA Repair Enhancement | Small molecules that enhance LIG1 activity or stability may protect neurons from DNA damage-induced death. |
| Gene Therapy | Viral vectors delivering functional LIG1 could potentially restore DNA repair capacity in affected neurons. |
| Associated Diseases | neurodegeneration |
| Interactions | MLH1, MSH2, MSH3, MSH6, PMS2 |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |