Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LIG3 |
| Full Name | DNA Ligase 3 |
| Chromosome | 17q12 |
| Protein Type | Enzyme |
| Function | DNA Ligase 3 is a key enzyme in DNA repair, participating in multiple DNA repair pathways. |
| Primary Expression | neurons and glia - High expression in regions with active DNA repair - Mitochondrial isoform important in high-energy demand neurons - Downregulated i |
| Subcellular Localization | s including nuclear and mitochondrial forms. Lig3 is particularly enriched in neural tissues, where its expression level |
| UniProt ID | P18858 |
| Ensembl ID | ENSG00000076544 |
| GeneCards | LIG3 |
| Human Protein Atlas | LIG3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LIG3["LIG3 DNA Ligase III"]
DNA_damage["DNA Damage"]
DSB["Double Strand Breaks"]
SSB["Single Strand Breaks"]
BER["Base Excision Repair"]
NHEJ["Non-Homologous End Joining"]
PARP1["PARP1"]
XRCC1["XRCC1"]
SOX2["SOX2 Transcription Factor"]
Mitochondria["Mitochondrial DNA Repair"]
ROS["Reactive Oxygen Species"]
Neuronal_death["Neuronal Cell Death"]
Neurodegeneration["Neurodegeneration"]
DNA_instability["Genomic Instability"]
DNA_damage -->|"causes"| DSB
DNA_damage -->|"causes"| SSB
ROS -->|"generates"| DNA_damage
DSB -->|"repaired by"| NHEJ
SSB -->|"repaired by"| BER
LIG3 -->|"essential for"| BER
LIG3 -->|"participates in"| NHEJ
LIG3 -->|"repairs"| Mitochondria
PARP1 -->|"recruits"| LIG3
XRCC1 -->|"scaffolds"| LIG3
SOX2 -->|"interacts with"| LIG3
DNA_instability -->|"leads to"| Neuronal_death
Neuronal_death -->|"causes"| Neurodegeneration
Mitochondria -->|"dysfunction leads to"| Neuronal_death
style LIG3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
style BER fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style NHEJ fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style Mitochondria fill:#1a3a2a,stroke:#81c784,stroke-width:2px
style SOX2 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style PARP1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style XRCC1 fill:#2a1a3a,stroke:#ce93d8,stroke-width:2px
style DNA_damage fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style ROS fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style DNA_instability fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style Neuronal_death fill:#3a1a1a,stroke:#ef5350,stroke-width:2px
style Neurodegeneration fill:#3a2a1a,stroke:#ffa726,stroke-width:3px| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LIG3 in their description or question text
No additional research found