protein

LIG3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LIG3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Dna Ligase Iii Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	LIG3PROTEIN
Protein Type	Ligase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	to both the nucleus and mitochondria
Molecular Weight	110 kDa
GeneCards	LIG3PROTEIN
Human Protein Atlas	LIG3PROTEIN
N-terminal BRCT Domain	Protein-protein interactions, XRCC1 binding (nuclear isoform)
NAD-dependent DNA Ligase Domain	Catalytic core
OB-fold Domain	DNA binding
C-terminal Zinc Finger	Protein interaction
DNA Ligase III-α	Nuclear isoform (~110 kDa), interacts with XRCC1
DNA Ligase III-β	Testis-specific isoform
Mitochondrial isoform	Alternative translation initiation (~95 kDa)
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DNA Ligase III Protein

protein · 951 words

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Pathway Diagram

graph TD
    LIG3PROTEIN["LIG3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    LIG3PROTEIN -->|"implicated_in"| neurodegeneration
    style LIG3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LIG3PROTEIN in their description or question text

No additional research found