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protein 951 words KG: LIG3PROTEIN 2026-03-30
kind:proteinsection:proteinsstate:published
Contents

DNA Ligase III Protein

🔬 Protein Info
Gene SymbolLIG3PROTEIN
Protein TypeLigase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localizationto both the nucleus and mitochondria
Molecular Weight110 kDa
GeneCardsLIG3PROTEIN
Human Protein AtlasLIG3PROTEIN
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67PARP1 Inhibition Therapy
Score: 0.58Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (16)

Epigenetic reprogramming in aging neurons
neurodegeneration · completedWhat determines the specificity of TDP-43-induced mitochondr
neurodegeneration · failedHow does chronic cGAS/STING activation downstream of TDP-43
neuroinflammation · failedWhat upstream mechanisms cause TDP-43 to trigger mPTP openin
neurodegeneration · failedHow do dilncRNAs specifically drive molecular crowding and p
neurodegeneration · completed

Related Experiments (30)

GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95Single-cell RNA-seq analysis of mouse testes with gonadal de
exploratory · proposed · Score: 0.95cGAS/STING pathway activation by TDP-43-released mtDNA
exploratory · proposed · Score: 0.95Factor depletion effects on DDR focus formation in vivo
exploratory · proposed · Score: 0.90Longitudinal TLR2 reporter gene study in α-synuclein mice
validation · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in
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