| Gene Symbol | LIG3PROTEIN |
| Protein Type | Ligase |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | to both the nucleus and mitochondria |
| Molecular Weight | 110 kDa |
| GeneCards | LIG3PROTEIN |
| Human Protein Atlas | LIG3PROTEIN |
| N-terminal BRCT Domain | Protein-protein interactions, XRCC1 binding (nuclear isoform) |
| NAD-dependent DNA Ligase Domain | Catalytic core |
| OB-fold Domain | DNA binding |
| C-terminal Zinc Finger | Protein interaction |
| DNA Ligase III-α | Nuclear isoform (~110 kDa), interacts with XRCC1 |
| DNA Ligase III-β | Testis-specific isoform |
| Mitochondrial isoform | Alternative translation initiation (~95 kDa) |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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