Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| GCase | inhibits | protein | 0.92 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop | 0.777 | alzheimers | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub | 0.776 | alzheimers | Cell type vulnerability in Alzheimers Di |
| LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul | 0.764 | alzheimers | Cell type vulnerability in Alzheimers Di |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| bEV isolation and LPS quantification from human samples | clinical | Alzheimer's disease | 0.800 | 0.00 | human patients | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in [PMID:38412923] | ["Zhang Tian-Ci", "Lin Yi-Can", "Sun Nin | Neurochemistry international | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Inflammatory Processes in Alzheimer's Disease-Pathomechanism, Diagnosis and Trea [PMID:37047492] | Unknown | Int J Mol Sci | 2023 | 0 |
| Ferroptosis Signaling Pathways: Alzheimer's Disease. [PMID:37257500] | Unknown | 2023 | 0 | |
| A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis [PMID:36438927] | Unknown | 2022 | 0 | |
| Pathogenesis of Alzheimer's Disease. [PMID:36613544] | Unknown | Int J Mol Sci | 2022 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Alzheimer's disease. [PMID:31753135] | ["Soria Lopez, Jose A", "Gonz\u00e1lez, | Handbook of clinical neurology | 2019 | 0 |
| Alzheimer's disease. [PMID:28872215] | ["Lane, C A", "Hardy, J", "Schott, J M"] | European journal of neurology | 2018 | 0 |
| Current understanding of Alzheimer's disease diagnosis and treatment. [PMID:30135715] | ["Weller, Jason", "Budson, Andrew"] | F1000Research | 2018 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LPC in their description or question text
No additional research found