Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GCase: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
A protein referenced in 5 knowledge graph relationships. Key connections: GBA1 (gene) encodes; maintains lysosomal_function (mechanism); alpha_synuclein_aggregation (mechanism) inhibits.
| Gene Symbol | GCASE |
| Primary Expression | Substantia Nigra |
| Pathways | Alpha-Synuclein, Unfolded Protein Response, Er Stress, Mitochondrial Function |
| GeneCards | GCASE |
| Human Protein Atlas | GCASE |
| Associated Diseases | disease |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GCASE["GCASE"]
GCASE -->|"cleaves"| Glucocerebrosides["Glucocerebrosides"]
GCASE -->|"causes"| Senescence["Senescence"]
GCASE -->|"causes"| Parkinson["Parkinson"]
GCASE -->|"causes"| Neurodegeneration["Neurodegeneration"]
GCASE -->|"causes"| Aging["Aging"]
GCASE -->|"interacts"| Ms["Ms"]
GBA["GBA"] -->|"encodes"| GCASE
PLIN2["PLIN2"] -->|"causes"| GCASE
ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"causes"| GCASE
NEURON["NEURON"] -->|"causes"| GCASE
AGING["AGING"] -->|"causes"| GCASE
PARKINSON["PARKINSON"] -->|"activates"| GCASE| Target | Relation | Type | Str |
|---|---|---|---|
| disease | associated_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GBA1 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||