Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LTBR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LTBR |
| Full Name | Lymphotoxin Beta Receptor |
| Chromosome | 12p13.31 |
| Protein Family | TNF Receptor Superfamily (TNFR3) |
| Protein Type | Receptor |
| Function | is a member of the tumor necrosis factor receptor (TNFR) superfamily, functioning as a critical signaling receptor for the lymphotoxin (LT) family of cytokines. |
| Subcellular Localization | Plasma membrane, endosomes |
| Molecular Weight | 61.7 kDa |
| Amino Acids | 435 aa |
| Pathways | NF-κB, MAPK |
| UniProt ID | [Q06643](https://www.uniprot.org/uniprot/Q06643) |
| Ensembl ID | ENSG00000111321 |
| GeneCards | LTBR |
| Human Protein Atlas | LTBR |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LTBR["LTBR"]
TNFSF14["TNFSF14"]
LTBR -->|"binds"| TNFSF14
beige_fat_biogenesis["beige fat biogenesis"]
LTBR -->|"inhibits"| beige_fat_biogenesis
JNK(["JNK"])
LTBR -->|"inhibits"| JNK
white_adipogenesis["white adipogenesis"]
LTBR -->|"inhibits"| white_adipogenesis
neurodegeneration["neurodegeneration"]
LTBR -->|"implicated in"| neurodegeneration
HCV_core_protein["HCV core protein"]
HCV_core_protein -->|"binds"| LTBR
TRAF5["TRAF5"]
TRAF5 -->|"interacts with"| LTBR
style LTBR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TNFSF14 | binds | entity | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LTBR in their description or question text
No additional research found