| Gene Symbol | LTBR |
| Chromosome | 12p13.31 |
| Protein Family | TNF Receptor Superfamily (TNFR3) |
| Protein Type | Receptor |
| Function | is a member of the tumor necrosis factor receptor (TNFR) superfamily, functioning as a critical signaling receptor for the lymphotoxin (LT) family of cytokines. |
| Subcellular Localization | Plasma membrane, endosomes |
| Molecular Weight | 61.7 kDa |
| Amino Acids | 435 aa |
| Pathways | NF-κB, MAPK |
| UniProt ID | [Q06643](https://www.uniprot.org/uniprot/Q06643) |
| Ensembl ID | ENSG00000111321 |
| GeneCards | LTBR |
| Human Protein Atlas | LTBR |
| Basal trafficking | Continuous recycling between plasma membrane and early endosomes |
| Ligand-induced internalization | LTα1β2 binding triggers receptor endocytosis, which can either attenuate or enhance downstream signaling depending on the context |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!