Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lipid Metabolism / Cholesterol Transport: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | participates_in | gene | 0.57 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| APOE Isoform Expression Across Glial Subtypes | 0.476 | Alzheimer's Disease | SEA-AD Gene Expression Profiling — Allen |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegene [PMID:37957317] | Maxine R Nelson, Peng Liu, Ayushi Agrawa | Nature neuroscience | 2023 | 1 |
| APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485] | Serrano-Pozo A, Das S, Hyman BT | Lancet Neurol | 2021 | 1 |
| Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456] | Long JM, Holtzman DM | Cell | 2019 | 1 |
| Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008] | Yamazaki Y, Zhao N, Caulfield TR, Liu CC | Nat Rev Neurol | 2019 | 1 |
| Perioperative polygenic and APOE-based genetic risk assessment for neurocognitiv [PMID:40562635] | Thedim M, Hu J, Maher M, Wiener-Kronish | Br J Anaesth | 2026 | 0 |
| Increased genetic protection against Alzheimer's disease in centenarians. [PMID:40615639] | Bae H, Song Z, Ali A, Sasaki T, Tesi N e | Geroscience | 2026 | 0 |
| Integrative machine learning approach to risk prediction for dementia and Alzhei [PMID:40864401] | Stern A, Linial M | Geroscience | 2026 | 0 |
| Adipose Tissue Macrophage-Derived Proplatelet Basic Protein Exacerbates Psoriasi [PMID:40886963] | Zhu L, Du L, Wu J, Ding D, Wang J et al. | J Invest Dermatol | 2026 | 0 |
| Targeting KAT8 alleviates vascular senescence by modulating the INHBA/TGF-β path [PMID:41445196] | Lin Z, Xiong J, Zhang F, Zhang H, Zhu M | Mol Ther | 2026 | 0 |
| Menopause, cognition, and Alzheimer's disease risk. [PMID:41531227] | Samudra N, Vemuri M, Weitlauf J | Curr Opin Obstet Gynecol | 2026 | 0 |
| ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in [PMID:41651379] | Huang X, Sun YY, Qin YR, Chen H, Pan TT | J Control Release | 2026 | 0 |
| Update on genetics of familial hypercholesterolemia. [PMID:41703706] | Freiberger T | Curr Opin Lipidol | 2026 | 0 |
| Inflammation-related miR-155-5p as an APOE ε4-modulated biomarker for amyloid pa [PMID:41930593] | Yoshida K, Saito N, Takahashi R, Ando S, | J Alzheimers Dis | 2026 | 0 |
| UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylati [PMID:41930933] | Ding SK | Immunol Invest | 2026 | 0 |
| Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR [PMID:41934727] | Li D, Zhang Y, Wang R, Jin L, Cui X et a | Neurotherapeutics | 2026 | 0 |
| Integrative multi-omics identifies a diagnostic T cell signature for cutaneous s [PMID:41935998] | Xu T, Yao G, Wang Y, Li W, Mou S et al. | Naunyn Schmiedebergs Arch Phar | 2026 | 0 |
| Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045] | Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O | Age Ageing | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760] | Bernocchi F, Bonomi CG, Poli M, Di Donna | Neurological sciences : offici | 2026 | 0 |
| Structural MRI phenotyping in Alzheimer's disease: Comparison of visual rating s [PMID:41943971] | Aracki-Trenkic A, Živanović M, Milošević | Biomol Biomed | 2026 | 0 |