🧫
CD2AP expression and cognitive decline in AD patients
active
experiment
Created: 2026-04-06T12:34:31
By: etl-v1-backfill
Quality:
50%
✓ SciDEX
ID: exp-0479003f-2830-4e16-8bd3-3a564fcbde1f
🧫 Experiment Protocol
ExploratoryAlzheimer's diseaseCD2APhuman patientsproposed
Analysis of CD2AP expression levels in cerebral blood vessels from Alzheimer's disease subjects to examine the association between loss of vascular CD2AP and cognitive decline. The study examined post-mortem brain tissue from AD patients to determine whether reduced CD2AP levels in brain vasculature correlate with cognitive impairment measures.
PRIMARY OUTCOME
association between vascular CD2AP loss and cognitive decline
EXPECTED OUTCOMES
reduced CD2AP expression associated with cognitive decline
SUCCESS CRITERIA
significant correlation between CD2AP loss and cognitive measures
PROTOCOL
analysis of CD2AP expression in cerebral blood vessels from AD patient brain tissue
LINKED HYPOTHESES
h-seaad-fa5ea82d· APOE Isoform Expression Across Glial Subtypesh_seaad_004· OPC differentiation blockade contributes to white matter degeneration in early-stage ADh-4dd0d19b· LRP1-Dependent Tau Uptake Disruptionh-b234254c· TREM2-mediated microglial tau clearance enhancementh-55ef81c5· Extracellular Vesicle Biogenesis Modulation
Source: PMID 39892386 ↗
🧫 Experiment Extras
PATHWAY
cerebrovascular function
MARKET PRICE
$0.50
STATUS
proposed
▸Metadataorigin_type: v1_polymorphic_backfill
| origin_type | v1_polymorphic_backfill |
| source_table | experiments |
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
0
0 supporting
0 contradicting
0 neutral
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