gene

MAP3K12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP3K12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

Summary

Page for MAP3K12 — Mitogen-Activated Protein Kinase Kinase Kinase 12

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🧬 Gene Info

Gene Symbol	MAP3K12
Full Name	Mitogen-Activated Protein Kinase Kinase Kinase 12
Protein Type	Kinase
Function	MAP3K12 (Mitogen-Activated Protein Kinase Kinase Kinase 12), also known as DLK (Dual-Leucine Zipper Kinase), is a serine/threonine protein kinase that functions as a key regulator of stress-activated
Primary Expression	neurons throughout the CNS - Regional Distribution: High expression in hippocampus, cortex
Pathways	MAPK pathway
GeneCards	MAP3K12
Human Protein Atlas	MAP3K12
Stress response	Activation of JNK/p38 pathways in response to oxidative stress, cytokines, and injury
Axonal injury signaling	Critical for axonal degeneration after injury (SARM1-independent pathway)
Synaptic plasticity	Regulates dendritic spine morphology and synaptic function
Axon guidance	Regulation of axonal pruning during development
Neuropathic pain	Sensitization of nociceptive neurons
Neurodegeneration	Activation of pro-apoptotic pathways
Brain	Widely expressed in neurons throughout the CNS
Associated Diseases	neurodegeneration
Interactions	DRP1
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["MAP3K12"]
    N1["Axonal Mitochondrial Fission"]
    N0 -->|"associated with"| N1
    N2["DRP1"]
    N0 -->|"phosphorylates"| N2
    N3["Apoptosis"]
    N0 -->|"associated with"| N3
    N4["Apoptotic Wave"]
    N0 -->|"associated with"| N4
    N5["neurodegeneration"]
    N0 -->|"implicated in"| N5

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 gene

Outgoing (4)

Target	Relation	Type	Str
Axonal Mitochondrial Fission	associated_with	process	0.95
DRP1	phosphorylates	gene	0.85
Apoptotic Wave	associated_with	process	0.85
Apoptosis	associated_with	process	0.85

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAP3K12

Understanding Entity Pages

Summary

Wiki Pages (8)

MAP3K12 — Mitogen-Activated Protein Kinase Kinase Kinase 12

Target Family Consolidation Analysis — Cross-Disease Therapeutic Targets

MLK3 (MAP3K12) Protein

MAP3K12 Protein — DLK (Dual-Leucine Zipper Kinase)

DLK Protein

DLK — Dual Leucine Zipper Kinase