Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MARCH5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MARCH5 |
| Protein Type | Ligase |
| Function | encodes a mitochondrial outer membrane E3 ubiquitin ligase that plays critical roles in mitochondrial quality control, dynamics, and innate immune signaling. |
| Subcellular Localization | mitochondrial membranes; MARCH5 helps clear Aβ-associated mitochondrial damage |
| Molecular Weight | 35.3 kDa |
| Amino Acids | 278 aa |
| Ensembl ID | ENSG00000148627 |
| GeneCards | MARCH5 |
| Human Protein Atlas | MARCH5 |
| Fission | Ubiquitinates DRP1 (Dynamin-related protein 1) to modulate its activity and turnover at mitochondrial fission sites |
| Fusion | Ubiquitinates and regulates turnover of MFN1 and MFN2 (Mitofusins) on the OMM |
| Net effect | MARCH5 loss causes excessive mitochondrial fragmentation due to uncontrolled DRP1 accumulation and reduced fusogenic capacity |
| Neurons | Moderate expression; essential for neuronal mitochondrial quality control |
| Brain regions | Enriched in substantia nigra, hippocampus, and cortex — regions with high mitochondrial metabolic demand |
| Heart and muscle | High expression; critical for cardiac mitochondrial homeostasis |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MARCH5["MARCH5"]
neurodegeneration["neurodegeneration"]
MARCH5 -->|"implicated_in"| neurodegeneration
style MARCH5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| USP14 | requires | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||