| Gene Symbol | MARCH5 |
| Protein Type | Ligase |
| Function | encodes a mitochondrial outer membrane E3 ubiquitin ligase that plays critical roles in mitochondrial quality control, dynamics, and innate immune signaling. |
| Subcellular Localization | mitochondrial membranes; MARCH5 helps clear Aβ-associated mitochondrial damage |
| Molecular Weight | 35.3 kDa |
| Amino Acids | 278 aa |
| Ensembl ID | ENSG00000148627 |
| GeneCards | MARCH5 |
| Human Protein Atlas | MARCH5 |
| Fission | Ubiquitinates DRP1 (Dynamin-related protein 1) to modulate its activity and turnover at mitochondrial fission sites |
| Fusion | Ubiquitinates and regulates turnover of MFN1 and MFN2 (Mitofusins) on the OMM |
| Net effect | MARCH5 loss causes excessive mitochondrial fragmentation due to uncontrolled DRP1 accumulation and reduced fusogenic capacity |
| Neurons | Moderate expression; essential for neuronal mitochondrial quality control |
| Brain regions | Enriched in substantia nigra, hippocampus, and cortex — regions with high mitochondrial metabolic demand |
| Heart and muscle | High expression; critical for cardiac mitochondrial homeostasis |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |