gene

MFRP

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about MFRP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

MFRP - Membrane Frizzled-Related Protein

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🧬 Gene Info

Gene Symbol	MFRP
Full Name	Membrane-Type Frizzled-Related Protein
Chromosome	11q14.1
Protein Type	Receptor
Function	is a member of the frizzled family of transmembrane receptors that play critical roles in the Wnt signaling pathway
Primary Expression	the retina and plays essential roles in:
Amino Acids	582 aa
UniProt ID	[Q9BYD4](https://www.uniprot.org/uniprot/Q9BYD4)
Ensembl ID	ENSG00000133105
OMIM	607502
GeneCards	MFRP
Human Protein Atlas	MFRP
Wnt/β-catenin pathway	Can either enhance or inhibit canonical Wnt signaling depending on cellular context
Planar Cell Polarity (PCP) pathway	Involved in non-canonical Wnt signaling affecting cytoskeletal organization
Frizzled receptor interactions	Forms heterodimers with other frizzled family members to modulate their activity
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MFRP - Membrane Frizzled-Related Protein

gene · 1377 words

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Genes

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Pathway Diagram

graph TD
    MFRP["MFRP"]
    neurodegeneration["neurodegeneration"]
    MFRP -->|"implicated_in"| neurodegeneration
    style MFRP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found