Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MITOCHONDRIAL CALCIUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Hepatic Mitochondrial Oxidation | associated_with | process | 0.80 |
| Succinate Dehydrogenase Flux | modulates | process | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Mitochondrial Calcium Buffering Enhancement via MCU Modulati | 0.650 | neurodegeneration | Selective vulnerability of entorhinal co |
| Mitochondrial Calcium Buffering Enhancement | 0.000 | - | Selective vulnerability of entorhinal co |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Exercise-BDNF-Mitophagy Biomarker Study in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| MLCS Quantification in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
| Wilson Disease Neurodegeneration: Mechanism and Therapeutic Response | clinical | Neurodegeneration | 0.400 | 0.50 | human | proposed | $7,500,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Mitochondrial calcium uptake declines during aging and is directly activated by [PMID:39603237] | Gherardi G, Weiser A, Bermont F, Migliav | Cell Metab | 2025 | 1 |
| Cytosolic calcium regulates hepatic mitochondrial oxidation, intrahepatic lipoly [PMID:39153480] | LaMoia TE, Hubbard BT, Guerra MT, Nasiri | Cell Metab | 2024 | 1 |
| Mitochondrial calcium exchange in physiology and disease. [PMID:34698550] | Garbincius JF, Elrod JW | Physiol Rev | 2022 | 1 |
| Ceritinib Induces Mitochondrial Fragmentation in Thyroid Cancer Cells by Targeti [PMID:41805100] | Qin D, Ding W, Wu X, Peng C, Bo Y et al. | Drug Dev Res | 2026 | 0 |
| Deficient Cardiolipin Remodelling Alters Muscle Fibre Composition and Neuromuscu [PMID:41841200] | Matias C, Snider PL, Sierra Potchanant E | J Cachexia Sarcopenia Muscle | 2026 | 0 |
| Zn(2+)-Dependent Modulation of the Mitochondrial Ca(2+) Uniporter Underlies Resv [PMID:41932596] | Xing B, Li X, Wang B, Huang L, Wang Q et | Exp Cell Res | 2026 | 0 |
| SERCA2 Dysfunction Drives Vascular Calcification via Coupling with TSPO-MCU at M [PMID:41932666] | Pi S, Liu W, Zhao J, Chen H, Luo X et al | Pharmacol Res | 2026 | 0 |
| Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU [PMID:39921279] | Zhao H, Chen S, Cao N, Wu W, Liu G, Gao | Advanced science (Weinheim, Ba | 2025 | 0 |
| Mitochondrial Calcium Uniporter Links Acetyl-CoA Metabolism and H3K27 Acetylatio [PMID:40712058] | Liu G, Zhang H, Chen S, Gao J, Zhao H, D | Cancer research | 2025 | 0 |
| Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567] | ["Porzuczek J"] | Sensors (Basel, Switzerland) | 2024 | 0 |
| A vision-based real-time traffic flow monitoring system for road intersections. [PMID:36789012] | ["Azimjonov J", "\u00d6zmen A", "Varan M | Multimedia tools and applicati | 2023 | 0 |
| Mitochondrial calcium cycling in neuronal function and neurodegeneration. [PMID:36760367] | Walters GC, Usachev YM | Frontiers in cell and developm | 2023 | 0 |
| The Mitochondrial Calcium Uniporter (MCU): Molecular Identity and Role in Human [PMID:37759703] | D'Angelo D, Rizzuto R | Biomolecules | 2023 | 0 |
| The Importance of Emotional Intelligence in University Athletes: Analysis of Its [PMID:36901234] | ["Mercader-Rubio I", "\u00c1ngel N"] | International journal of envir | 2023 | 0 |
| Synergistic Antitumoral Effect of Epigenetic Inhibitors and Gemcitabine in Pancr [PMID:35890123] | ["Maietta I", "Mart\u00ednez-P\u00e9rez | Pharmaceuticals (Basel, Switze | 2022 | 0 |
| The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liabi [PMID:34789012] | ["Mahjani B", "Klei L", "Mattheisen M", | The American journal of psychi | 2022 | 0 |
| Controlled synthesis of silver-based ternary quantum dots with outstanding lumin [PMID:35678901] | ["Mbaz G", "Parani S", "Oluwafemi O"] | Journal of fluorescence | 2022 | 0 |
| Multiple Primary Malignancies in Head and Neck Cancer: A University Hospital Exp [PMID:34567890] | ["Batista MV", "Ulrich J", "Costa L", "R | Cureus | 2021 | 0 |
| Early treatment with sumatriptan prevents PACAP38-induced migraine: A randomised [PMID:33567890] | ["Wienholtz N", "Christensen C", "Zhang | Cephalalgia : an international | 2021 | 0 |
| Severe vernal keratoconjunctivitis complicated by anaesthetic abuse [PMID:32456789] | Anchouche Sonia; Yin Jia | Canadian Journal of Ophthalmol | 2020 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning MITOCHONDRIAL CALCIUM in their description or question text
No additional research found