entity

MPO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

30Hypotheses

0Analyses

2Outgoing

1Incoming

5Experiments

0Debates

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Wiki Pages (4)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Neutrophil Extracellular Trap Formation	involved_in	process	0.80

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Optimized Temporal Window for Metabolic Boosting Therapy Det	0.887	neurodegeneration	How do different microglial subtypes (DA
Thalamocortical Feedforward Inhibition Imposes Rhythm on Gly	0.808	neuroscience	GluN2B-Mediated Thalamocortical Control
Temporal SPP1 Inhibition During Critical Windows	0.752	neuroinflammation	What molecular mechanisms mediate SPP1-i
Temporal order is subtype-specific rather than universal	0.730	neurodegeneration	What determines the temporal sequence of
Compromised Lysosomal Acidification and Trafficking Due to N	0.718	neurodegeneration	What mechanisms underlie neuronal resist

H4: Senomorphic Compounds Preserve Astrocyte Function While	0.710	neurodegeneration	Do APOE4-driven senescent astrocytes cau
Spatiotemporal coupling between TRPML1-mediated lysosomal ca	0.705	neurodegeneration	What determines the specificity of calci
Temporal Microglial State Switching	0.695	-	Neuroinflammation and microglial priming
Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi	0.681	neurodegeneration	CRISPR-based therapeutic approaches for
Flotillin-1 Stabilization Compounds	0.681	neurodegeneration	Lipid raft composition changes in synapt
Gamma entrainment corrects AD-related clock gene dysregulati	0.676	alzheimers	Gamma entrainment therapy to restore hip
Temporal TET2-Mediated Hydroxymethylation Cycling	0.657	neurodegeneration	Epigenetic reprogramming in aging neuron
Microglial TBK1 Deficiency Triggers Senescence-Associated Se	0.650	frontotemporal-dementia	-
ISR/eIF2α~P Overflow Represses Synaptic Proteostasis in Cort	0.650	frontotemporal-dementia	-
Layer-Specific Excitatory Neuron Vulnerability in Temporal C	0.636	neurodegeneration	Methodology challenge: dataset 'Allen Br
Temporal TFEB Modulation Therapy	0.609	neurodegeneration	Does TFEB dysfunction cause neurodegener
Neurovascular Permeability Score (NVPS): Composite Plasma +	0.600	-	Blood-brain barrier permeability changes
Temporal Decoupling of CSF p-tau217 Normalization from Amylo	0.595	neurodegeneration	-
Residual Vascular Amyloid Prevents Complete CSF p-tau217 Nor	0.585	-	Can CSF p-tau217 normalization serve as
Multi-Biomarker Composite Index Surpassing Amyloid PET for T	0.579	neurodegeneration	Multi-modal Biomarker Panel Design for E
Temporal Gating of Microglial Responses	0.565	alzheimers	Neuroinflammation and microglial priming
A genetically encoded reporter for axonal mitochondrial prot	0.565	neuroscience	How can subcellular compartmentalization
Temporal cGAS-STING Activation Stage-Specific Therapeutic Ta	0.560	neuroinflammation	How does chronic cGAS/STING activation d
Temporal NLRP3 Inhibition During SPP1-Driven Microglial Acti	0.551	neuroinflammation	What molecular mechanisms mediate SPP1-i
Small-Molecule FUS Nuclear Import Correctors Rescue Motor Ne	0.550	neurodegeneration	Test Hypothesis Fixtures
Temporal Decoupling via Circadian Clock Reset	0.543	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Synaptic Vulnerability Window Temporal Targeting: Transient	0.536	synaptic-biology	Does SPP1-mediated synaptic engulfment r
Temporal Metabolic Window Therapy	0.525	neurodegeneration	How do astrocyte-neuron metabolic intera
Temporal NLRP3 Inhibition via SPP1-Mediated Mitophagy Enhanc	0.496	neuroinflammation	What molecular mechanisms mediate SPP1-i
eIF2α Phosphorylation Imbalance Disrupts Mitochondrial Prote	0.000	als	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
SPP1 upregulation in perivascular cells in AD mouse models	exploratory	Alzheimer's disease	0.900	0.00	AD mouse models	proposed	N/A
Spp1 knockout prevents synaptic loss in AD mouse models	validation	Alzheimer's disease	0.900	0.00	Spp1 knockout AD mouse models	proposed	N/A
Single-cell RNA sequencing of microglial states in AD hippocampus	exploratory	Alzheimer's disease	0.850	0.00	AD mouse hippocampus	proposed	N/A
Cell-cell interaction analysis of perivascular-microglial crosstalk	exploratory	Alzheimer's disease	0.800	0.00	AD mouse models	proposed	N/A
Basic Mechanism: Membrane-Driven Alpha-Synuclein Nucleation	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279]	Saffire H Krance, Che-Yuan Wu, Alison C	Journal of Alzheimer's disease	2022	1
Mismatch repair MLH complexes make distinct contributions to post-replicative mi [PMID:41648604]	Casazza KM, Williams GM, Johengen L, Kel	bioRxiv	2026	0
Membrane remodeling and higher-order structure formation by DivIVA. [PMID:41819316]	Labajová N, Obořilová R, Pinkas D, Přiby	Int J Biol Macromol	2026	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
Flotillin-1 palmitoylation is essential for its stability and subsequent tumor p [PMID:38374406]	McClellan B, Wilson CN, Brenner AJ, Joll	Oncogene	2024	0
FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signa [PMID:37928269]	Wang R, Huang W, Cai K, Xiao S, Zhang W,	International journal of biolo	2023	0
SDC1-TGM2-FLOT1-BHMT complex determines radiosensitivity of glioblastoma by infl [PMID:37441590]	["Zeng L", "Zheng W", "Liu X", "Zhou Y",	Theranostics	2023	0
The roles of FLOT1 in human diseases (Review). [PMID:37772385]	Zhan Z, Ye M, Jin X	Molecular medicine reports	2023	0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020	0
Perindopril ameliorates experimental Alzheimer's disease progression: role of am [PMID:32488543]	Messiha BAS, Ali MRA, Khattab MM, Abo-Yo	Inflammopharmacology	2020	0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020	0
Flotillin membrane domains in cancer. [PMID:32297092]	["Gauthier-Rouvi\u00e8re C", "Bodin S",	Cancer metastasis reviews	2020	0
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018	0
Prognostic value of flotillins (flotillin-1 and flotillin-2) in human cancers: A [PMID:29499201]	["Deng Y", "Ge P", "Tian T", "Dai C", "W	Clinica chimica acta; internat	2018	0
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflam [PMID:29540215]	["Wu B", "Liu J", "Zhao R", "Li Y", "Pee	Journal of neuroinflammation	2018	0
Cellular uptake of extracellular vesicles is mediated by clathrin-independent en [PMID:28919558]	Costa Verdera H, Gitz-Francois JJ, Schif	Journal of controlled release	2017	0
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in L [PMID:29166931]	Wang S, Liu Z, Ye T, Mabrouk OS, Maltbie	Acta neuropathologica communic	2017	0
A role for lipid rafts in the protection afforded by docosahexaenoic acid agains [PMID:23907024]	["Aliche-Djoudi F", "Podechard N", "Coll	Food and chemical toxicology :	2013	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MPO in their description or question text

H4: Senomorphic Compounds Preserve Astrocyte Function While Reversing Senescence

Score: 0.710 · neurodegeneration · 2026-04-22

## Mechanistic Overview H4: Senomorphic Compounds Preserve Astrocyte Function While Reversing Senescence starts from the

Spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and ca

Score: 0.705 · neurodegeneration · 2026-04-21

**Molecular Mechanism and Rationale** The spatiotemporal coupling between TRPML1-mediated lysosomal calcium release and

Temporal Microglial State Switching

Score: 0.695 · unknown disease · 2026-04-04

## Mechanistic Overview Temporal Microglial State Switching starts from the claim that modulating Optogenetic constructs

Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modula

Score: 0.681 · neurodegeneration · 2026-04-04

## Mechanistic Overview Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mismatch Repair Modulation starts from

Flotillin-1 Stabilization Compounds

Score: 0.681 · neurodegeneration · 2026-04-02

## Mechanistic Overview Flotillin-1 Stabilization Compounds starts from the claim that modulating FLOT1 within the disea

Gamma entrainment corrects AD-related clock gene dysregulation to normalize hipp

Score: 0.676 · alzheimers · 2026-04-28

Alzheimer's pathology disrupts circadian PER1/2 and BMAL1 rhythms in hippocampal neurons. Gamma entrainment, particularl

Temporal TET2-Mediated Hydroxymethylation Cycling

Score: 0.657 · neurodegeneration · 2026-04-02

## Mechanistic Overview Temporal TET2-Mediated Hydroxymethylation Cycling starts from the claim that modulating TET2 wit

Layer-Specific Excitatory Neuron Vulnerability in Temporal Cortex

Score: 0.636 · neurodegeneration · 2026-04-28

Layer 2/3 excitatory neurons show transcriptional signature of endoplasmic reticulum stress and mitochondrial dysfunctio

Temporal TFEB Modulation Therapy

Score: 0.609 · neurodegeneration · 2026-04-04

## Mechanistic Overview Temporal TFEB Modulation Therapy starts from the claim that modulating TFEB within the disease c

Neurovascular Permeability Score (NVPS): Composite Plasma + Imaging Biomarker Pa

Score: 0.600 · unknown disease · 2026-04-26

A LASSO-optimized composite score integrating plasma GFAP, S100B, NFL, soluble PDGFR-β, and claudin-5 fragments to achie

Residual Vascular Amyloid Prevents Complete CSF p-tau217 Normalization, Requirin

Score: 0.585 · unknown disease · 2026-04-26

Cerebral amyloid angiopathy (CAA) maintains a reservoir of vascular amyloid that continues to drive tau pathology even a

Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Pr

Score: 0.579 · neurodegeneration · 2026-04-16

## Mechanistic Overview Multi-Biomarker Composite Index Surpassing Amyloid PET for Treatment Response Prediction starts

MPO