Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MPO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Neutrophil Extracellular Trap Formation | involved_in | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Temporal SPP1 Inhibition During Critical Windows | 0.650 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
| Temporal Decoupling via Circadian Clock Reset | 0.516 | neurodegeneration | Microglia-astrocyte crosstalk amplificat |
| Temporal CAG Repeat Stabilization via CRISPR-Mediated DNA Mi | 0.511 | neurodegeneration | CRISPR-based therapeutic approaches for |
| Temporal Metabolic Window Therapy | 0.506 | neurodegeneration | How do astrocyte-neuron metabolic intera |
| Temporal Microglial State Switching | 0.462 | - | Neuroinflammation and microglial priming |
| Flotillin-1 Stabilization Compounds | 0.422 | neurodegeneration | Lipid raft composition changes in synapt |
| Temporal TET2-Mediated Hydroxymethylation Cycling | 0.408 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Temporal Gating of Microglial Responses | 0.389 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Temporal TFEB Modulation Therapy | 0.366 | neurodegeneration | Does TFEB dysfunction cause neurodegener |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 2 hypotheses Top: 0.674
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645
neurodegeneration | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Heal [PMID:40588189] | Bishehsari F, Post Z, Swanson GR, Keshav | Gastroenterology | 2025 | 1 |
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| Circadian disruption, clock genes, and metabolic health. [PMID:39007272] | Schrader LA, Ronnekleiv-Kelly SM, Hogene | J Clin Invest | 2024 | 1 |
| Biomarkers of aging for the identification and evaluation of longevity intervent [PMID:37657418] | Moqri M, Herzog C, Poganik JR, Biomarker | Cell | 2023 | 1 |
| Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279] | Saffire H Krance, Che-Yuan Wu, Alison C | Journal of Alzheimer's disease | 2022 | 1 |
| Clocks, cancer, and chronochemotherapy. [PMID:33384351] | Sancar A, Van Gelder RN | Science | 2021 | 1 |
| The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663] | Krasemann S, Madore C, Cialic R, Baufeld | Immunity | 2017 | 1 |
| Epigenetics and the gut-brain axis: Insights into DNA methylation, aging, and Al [PMID:41886887] | Kumar V, Shukla R, Gangani S, Joseph R, | The Journal of pharmacology an | 2026 | 0 |
| Effects of circadian rhythms on antimicrobial peptide concentrations in lactatin [PMID:41923233] | Liang ZL, Nii T, Sugino T, Isobe N | BMC veterinary research | 2026 | 0 |
| Multifunctional hydrogel delivery of mesenchymal stem cell secretome suppresses [PMID:41092646] | Lin L, Liang X, Xu Z, Li Y, Guo Z et al. | Biomaterials | 2026 | 0 |
| Pharmacological modulation of circadian rhythms in brain microvasculature. [PMID:41355044] | Yang Z, Kim M, Montgomery M, Lewandowski | J Cereb Blood Flow Metab | 2026 | 0 |
| The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mit [PMID:41486525] | Sica V, Sato T, Tsialtas I, Hernandez S, | J Biol Rhythms | 2026 | 0 |
| When Clocks Go Rogue: Circadian Rhythms and the Rise of Cancer. [PMID:41520235] | Robinson AS, Bennett S, Sato S | J Biol Rhythms | 2026 | 0 |
| Glycaemic, appetite and circadian benefits of a dairy-enriched diet with high-pr [PMID:41578008] | Tsameret S, Froy O, Matz Y, Landau Z, Tw | Diabetologia | 2026 | 0 |
| Circadian locomotor activity-rest rhythm in Drosophila is regulated by microRNA- [PMID:41632758] | Anna G, Tharayil Jayalal N, Jayan A, Ran | Genetics | 2026 | 0 |
| Lifestyle factors and DNA methylation-based aging clocks: cross-sectional and lo [PMID:41763011] | Shan J, Tay JH, Ye KX, Guo J, Cao L et a | J Prev Alzheimers Dis | 2026 | 0 |
| Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses [PMID:41785851] | Zhao H, Liao M, Huo R, He T, Tian H et a | Cell | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |
| Integrative Dermatology for Longevity: The Synergy of Topical and Internal Appro [PMID:41926038] | Haykal D, Flament F, Balooch G, Mora P, | Dermatol Ther (Heidelb) | 2026 | 0 |
| Could automated net water uptake turn a non-contrast brain CT scan into a potent [PMID:41931168] | Festas G | European radiology | 2026 | 0 |