gene

MYPN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MYPN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive page on MYPN (Myopalladin), a Z-disc protein critical for sarcomere assembly and implicated in cardiomyopathy and nemaline myopathy.

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🧬 Gene Info

Gene Symbol	MYPN
Aliases	Myopalladin
Chromosome	10q21.3
Function	encodes a critical Z-disc protein that plays essential roles in sarcomere organization, assembly, and maintenance in both skeletal and cardiac muscle.
Molecular Weight	162 kDa
Amino Acids	456 aa
Exons	30
Ensembl ID	ENSG00000138379
GeneCards	MYPN
Human Protein Atlas	MYPN
Skeletal Muscle	High expression in all major skeletal muscle groups, with particularly abundant levels in type 1 (slow-twitch) fibers.
Cardiac Muscle	Very high expression in both ventricular and atrial myocardium, reflecting the protein's critical role in cardiac function.
Smooth Muscle	Low to undetectable expression in most smooth muscle populations.
Non-muscle Tissues	Minimal expression outside of muscle tissues, confirming its role as a muscle-specific protein.
Alpha-actinin binding	Myopalladin directly binds to alpha-actinin, the primary cross-linking protein at the Z-disc. This interaction is essential for forming the lattice-like structure of the Z-disc.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

MYPN Gene

gene · 2357 words

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Pathway Diagram

graph TD
    MYPN["MYPN"]
    neurodegeneration["neurodegeneration"]
    MYPN -->|"implicated_in"| neurodegeneration
    style MYPN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning MYPN in their description or question text

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