Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Microglial homeostasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| 40806186 | aim to restore | paper | 0.90 |
| SCFA-producing bacteria | regulates | cell_type | 0.70 |
| CX3CR1 | maintains | gene | 0.70 |
| HDAC inhibition | regulates | mechanism | 0.70 |
| mitophagy | protects_against | process | 0.70 |
| P2RY12 | regulates | protein | 0.70 |
| TREM2-APOE pathway | modulates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SCFA Deficiency Disrupts Microglial Homeostasis and Promotes | 0.583 | neurodegeneration | Gut-Brain Axis in Parkinson's Disease: M |
| TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeosta | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630
neurodegeneration | 2026-04-26 | 0 hypotheses
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
neuroinflammation | 2026-04-08 | 7 hypotheses Top: 0.455
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty [PMID:40254847] | Meiying Song, Shanshan Zhang, Yuxin Gan | {'name': 'Journal of agricultu | 2025 | 0 |
| Molecular Mechanisms Underlying the Regulation of VCAM-1 Expression by the Short [PMID:41473323] | Vrishali S. Salian, Vaishnavi Veerareddy | {'name': 'bioRxiv'} | 2025 | 0 |
| Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and [PMID:38377788] | Kalyanaraman B, Cheng G, Hardy M | Redox biology | 2024 | 0 |
| Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammatio [PMID:38869276] | Atreye Majumdar, Indira Priya Siva Venka | {'name': 'mBio', 'volume': '15 | 2024 | 0 |
| Rosiglitazone synergizes the neuroprotective effects of valproic acid against qu [PMID:24566814] | Mishra J, Chaudhary T, Kumar A | Neurotox Res | 2014 | 0 |
| Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone d [PMID:17398106] | Sinn DI, Kim SJ, Chu K | Neurobiol Dis | 2007 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.60 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 6 · Score: 0.50 · 2026-04-25
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.86 · 2026-04-09
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning Microglial homeostasis in their description or question text
No additional research found