pathway

mitophagy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about mitophagy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5988Connections

4Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

mitophagy is a biological pathway involved in neurodegeneration research. Key relationships include: regulates, activates, inhibits. Associated with Alzheimer's disease, Parkinson's disease, cerebral ischemia/reperfusion injury. Connected to 150 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	mitophagy
Summary	Page for Mitophagy Enhancer Prophylaxis for Pre-Symptomatic Parkinson's and Related Neurodegeneration
Key Genes/Proteins	PINK1, SQSTM1, FDX1, MANF, PARKIN, OPTN
Related Diseases	breast cancer cell survival, mutant mtDNA clearance
Related Pathways	PINK1-Parkin pathway
Linked Hypotheses	5 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Mitophagy Enhancer Prophylaxis for Pre-Symptomatic Parkinson's and Related Neurodegeneration

idea · 546 words

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Pathway Diagram

graph TD
    mitophagy["mitophagy"] -.->|"inhibits"| apoptosis["apoptosis"]
    mitophagy["mitophagy"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    mitophagy["mitophagy"] -->|"causes"| hormone_resistance["hormone resistance"]
    mitophagy["mitophagy"] -->|"associated"| neurodegeneration["neurodegeneration"]
    mitophagy["mitophagy"] -->|"protects against"| neurodegenerative_diseases["neurodegenerative diseases"]
    mitophagy["mitophagy"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    PINK1["PINK1"] -->|"regulates"| mitophagy["mitophagy"]
    CKLF["CKLF"] -.->|"inhibits"| mitophagy["mitophagy"]
    CLOCK["CLOCK"] -->|"regulates"| mitophagy["mitophagy"]
    AMPK_ULK1_pathway["AMPK/ULK1 pathway"] -->|"activates"| mitophagy["mitophagy"]
    style mitophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2543)

Target	Relation	Type	Str
mitochondrial quality control	promotes	process	0.95
breast cancer cell survival	promotes	phenotype	0.95
mutant mtDNA clearance	promotes	phenotype	0.92
apoptosis	inhibits	phenotype	0.90
cellular homeostasis	promotes	process	0.90
cellular senescence	protects_against	phenotype	0.90
cellular homeostasis	maintains	process	0.90
mitochondrial dysfunction	prevents	phenotype	0.90
hepatocellular carcinoma	therapeutic_target	disease	0.90
ROS production	reduces	phenotype	0.90
carnitine metabolism	regulates	pathway	0.90
damaged mitochondria	involved_in	organelle	0.90
motor neuron degeneration	protects_against	phenotype	0.90
damaged mitochondria clearance	mediates	process	0.90
cellular homeostasis	associated_with	process	0.90
astrocytes	expressed_in	cell_type	0.90
neuroprotection	promotes	process	0.88
Alzheimer's disease	prevents	disease	0.88
mitochondrial quality control	involved_in	pathway	0.88
intervertebral disc degeneration	upstream_of	disease	0.87
aging	protects_against	phenotype	0.85
mitochondrial dynamics	modulates	process	0.85
breast cancer	promotes	disease	0.85
NASH	protects_against	disease	0.85
NADK2	modulates	protein	0.85
NADK2	regulates	protein	0.85
Alzheimer's disease	protects_against	disease	0.80
hormone resistance	causes	phenotype	0.80
renal fibrosis	prevents	disease	0.80
endometrial cancer cell proliferation	promotes	process	0.80
ATP production	regulates	process	0.80
neuroprotection	mediates	phenotype	0.80
neurodegenerative diseases	protects_against	disease	0.70
Parkinson's disease	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
damaged organelles	inhibits	cell_type	0.70
neuronal cell death	protects_against	process	0.70
inflammatory disorders	protects_against	disease	0.70
neurodegeneration	protects_against	disease	0.70
mitochondrial quality control	regulates	process	0.70
organelle quality control	regulates	process	0.70
cognitive impairments	protects_against	process	0.70
neurodegenerative diseases	associated_with	disease	0.70
neurological diseases	associated_with	disease	0.70
cognitive impairment	protects_against	disease	0.70
NF-κB signaling	associated_with	pathway	0.70
cellular homeostasis	regulates	process	0.70
mitochondrial quality	regulates	process	0.70
cell differentiation	activates	process	0.70
apoptosis	activates	process	0.70

Incoming (3445)

Source	Relation	Type	Str
PINK1	regulates	protein	0.95
SQSTM1	activates	protein	0.95
FDX1	regulates	gene	0.95
PINK1	promotes	gene	0.95
MANF	promotes	protein	0.95
PARKIN	promotes	protein	0.95
OPTN	initiates	protein	0.95
PINK1	mediates	gene	0.95
PINK1-Parkin pathway	mediates	pathway	0.95
CLEC16A	promotes	gene	0.92
LC3	biomarker_for	protein	0.92
LC3-II	biomarker_for	protein	0.92
HK2	regulates	gene	0.92
PRKN	promotes	protein	0.92
CKLF	inhibits	protein	0.90
CLOCK	regulates	gene	0.90
AMPK/ULK1 pathway	activates	pathway	0.90
BECN1	associated_with	gene	0.90
BEX2	activates	protein	0.90
GBA	inhibits	gene	0.90
TGFB1	activates	protein	0.90
SMAD2	regulates	protein	0.90
SMAD3	regulates	protein	0.90
SMAD4	regulates	protein	0.90
BNIP3L	participates_in	protein	0.90
BNIP3	participates_in	protein	0.90
FUNDC1	participates_in	protein	0.90
PRKN	activates	gene	0.90
MANF	activates	protein	0.90
UMI-77	activates	drug	0.90
MCL-1	participates_in	protein	0.90
BNIP3	activates	protein	0.90
BNIP3 deficiency	inhibits	phenotype	0.90
PINK1	activates	protein	0.90
PARKIN	activates	protein	0.90
SIRT3	activates	protein	0.90
ATAD3A	inhibits	protein	0.90
T3	activates	drug	0.90
MTOR	inhibits	gene	0.90
ROS	activates	phenotype	0.90
P62	biomarker_for	protein	0.90
Lycopene	activates	drug	0.90
PRDX6	inhibits	protein	0.90
MIZ1	promotes	protein	0.90
TFEB	promotes	protein	0.90
TFE3	promotes	protein	0.90
SYK	modulates	protein	0.90
USP25	inhibits	protein	0.90
isoginkgetin	activates	compound	0.90
SIRT3	upstream_of	protein	0.89

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
NLRP3/Mitophagy Coupling Modulation	0.522	Neuroinflammation	Immune atlas neuroinflammation analysis
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.509	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
PGC1α Activation in PV+ Interneurons Bypasses Mitophagy Defi	0.455	neurodegeneration	Why does PRKN-mediated mitophagy, typica
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.418	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189]	["Cho S", "Jo E", "Jang H"]	Scientific reports	2026
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026
AARS2 R199C mutation induces lactylation-driven premature ovarian insufficiency [PMID:41832996]	Zhang HH, Zhang ZL, Xu W	Reproduction	2026
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026
FGFR1 suppresses ovarian cancer progression by modulating SIRT3-dependent lactyl [PMID:41946672]	Jiang F, Huang H, Dong Z, Zhang L, Zhang	Cell Death Discov	2026
Adipocyte small extracellular vesicle-derived microRNA-30a-3p exacerbates hepati [PMID:41965824]	Zhang T, Hu L, Chen D, Chen Y, Zhou F et	Nat Commun	2026
α7-nAChR activation mitigates pyridaben-induced hepatotoxicity in grass carp (Ct [PMID:41966317]	Wu C, Jiang J, Qiu H, Xie J, Li S	Fish Shellfish Immunol	2026
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Fang Y, Deng M, Huang K, Song H, Chu Y,	Cell communication and signali	2026
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026
Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832]	["Tang M", "Outissint I", "Chen Y", "Gon	Journal of cellular biochemist	2025
H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alz [PMID:39862777]	Wang H, Xia H, Bai J, Wang Z, Wang Y et	J Hazard Mater	2025
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic [PMID:40826276]	Weber ANR, McManus RM, Hornung V, Geyer	Nat Immunol	2025
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025

mitophagy

Understanding Entity Pages

Summary

Wiki Pages (21)

Mitophagy Enhancer Prophylaxis for Pre-Symptomatic Parkinson's and Related Neurodegeneration

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Pathway Diagram

Outgoing (2543)

Incoming (3445)

Targeting Hypotheses (4)

Mentioning Analyses (3)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

How do different organelle-specific autophagy pathways coordinate during neurode

Related Papers (20)

mitophagy

Understanding Entity Pages

Summary

Wiki Pages (21)

Mitophagy Enhancer Prophylaxis for Pre-Symptomatic Parkinson's and Related Neurodegeneration

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

CBS/PSP Supplements Guide

Neuroresilience Mechanisms and Evidence

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

PD Cure Roadmap

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Circadian Rhythm in Neurodegeneration

Synucleinopathy Mechanism

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

Pathway Diagram

Outgoing (2543)

Incoming (3445)

Targeting Hypotheses (4)

Mentioning Analyses (3)

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

How do different organelle-specific autophagy pathways coordinate during neurode

Related Papers (20)