Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Mitochondrial delivery: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Extracellular Vesicles | causes | phenotype | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m | 0.621 | neurodegeneration | Mitochondrial transfer between astrocyte |
| Microglia-Derived Extracellular Vesicle Engineering for Targ | 0.482 | neurodegeneration | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Axonal Transport Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745] | Rydzanicz M, Jagła M, Kosinska J, Tomasi | Clin Genet | 2017 | 1 |
| TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375] | van Spronsen M, Mikhaylova M, Lipka J, S | Neuron | 2013 | 1 |
| Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670] | Randall TS, Moores C, Stephenson FA | FEBS Lett | 2013 | 1 |
| Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-res [PMID:41787360] | ["Xiang S", "Qin T", "Qin Y", "Sun Y", " | Journal of nanobiotechnology | 2026 | 0 |
| hUC-MSC-derived exosomes ameliorate Alzheimer's disease pathology through lncRNA [PMID:41540476] | Zhang Y, Zhang F, Yin H, Sun Y, Wang Y, | Alzheimer's research & therapy | 2026 | 0 |
| Engineered Biomimetic Nanorobots Orchestrate Targeted Nose-to-Brain Delivery to [PMID:41607240] | ["Xu Y", "Zhao J", "Xu X", "Liu Y", "Li | Small (Weinheim an der Bergstr | 2026 | 0 |
| Engineering integrin αvβ8-targeted extracellular vesicles to deliver BDNF mRNA f [PMID:41749221] | ["Shie M", "Chiu C", "Chen Y", "Lin Y", | Journal of nanobiotechnology | 2026 | 0 |
| Extracellular vesicles: A new therapeutic drug for nerve injury repair. [PMID:41467441] | ["Cai J", "Ren C", "Wang C", "Shen S", " | Neural regeneration research | 2025 | 0 |
| Engineered extracellular vesicles-mediated curcumin delivery in brain microenvir [PMID:41390406] | ["Shie M", "Chen M", "Chen Y", "Huang S" | Journal of nanobiotechnology | 2025 | 0 |
| Therapeutic developments in pancreatic cancer. [PMID:37798442] | ["Hu Z", "O'Reilly E"] | Nature reviews. Gastroenterolo | 2024 | 0 |
| Rab27a-mediated exosome secretion in anterior cingulate cortex contributes to co [PMID:37529842] | Sun Q, Weng RX, Li JH, Li YC, Xu JT, Li | American journal of physiology | 2023 | 0 |
| Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles [PMID:33282910] | van Solinge TS, Abels ER, van de Haar LL | Frontiers in molecular bioscie | 2020 | 0 |
| Adapting Drosophila melanogaster Cell Lines to Serum-Free Culture Conditions. [PMID:33028628] | Luhur A, Mariyappa D, Klueg KM, Buddika | G3 (Bethesda, Md.) | 2020 | 0 |
| Defining treatment-resistant depression. [PMID:31638723] | ["Gaynes B", "Lux L", "Gartlehner G", "A | Depression and anxiety | 2020 | 0 |
| Predictive Role of High Blood Pressure for the Incidence of Metabolic Syndrome. [PMID:31261156] | Presta V, Miceli F, Tocci G | Cardiology | 2019 | 0 |
| Metformin use and risk of gastric adenocarcinoma in a Swedish population-based c [PMID:31591459] | Zheng J, Xie SH, Santoni G, Lagergren J | British journal of cancer | 2019 | 0 |
| Aiming for the target: Mitochondrial drug delivery in traumatic brain injury. [PMID:30009835] | Lamade AM, Kenny EM, Anthonymuthu TS, So | Neuropharmacology | 2019 | 0 |
| A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illumina [PMID:30816224] | Neckles VN, Morton MC, Holmberg JC, Soko | Scientific reports | 2019 | 0 |
| Emerging trends in global freshwater availability. [PMID:29769728] | ["Rodell M", "Famiglietti J", "Wiese D", | Nature | 2018 | 0 |
| The Science and Translation of Lactate Shuttle Theory. [PMID:29617642] | Brooks GA | Cell metabolism | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.71 · 2026-04-12
closed · Rounds: 4 · Score: 0.81 · 2026-04-06
Hypotheses and analyses mentioning Mitochondrial delivery in their description or question text
No additional research found