concept

EXTRACELLULAR VESICLES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EXTRACELLULAR VESICLES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

154Connections

0Hypotheses

4Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	EXTRACELLULAR VESICLES
Key Genes/Proteins	RAB27A
Related Diseases	Sepsis, cancer, TUMOR, Fatty Liver
Related Pathways	Pi3K, Pi3K/Akt

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Corticobasal Syndrome (CBS)

disease · 11374 words

→

Parkinson's Disease

disease · 8807 words

→

Pathway Diagram

graph TD
    EXTRACELLULAR_VESICLES["EXTRACELLULAR VESICLES"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Liver["Liver"]
    EXTRACELLULAR_VESICLES -->|"modulates"| Tumor_Microenvironment["Tumor Microenvironment"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Angiogenesis["Angiogenesis"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Intercellular_Communication["Intercellular Communication"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Metabolic_Dysfunction["Metabolic Dysfunction"]
    EXTRACELLULAR_VESICLES -->|"promotes"| dopaminergic_cell_death["dopaminergic cell death"]
    EXTRACELLULAR_VESICLES -.biomarker for.-> Sarcopenia["Sarcopenia"]
    EXTRACELLULAR_VESICLES -->|"mediates"| Mitochondrial_Targeting["Mitochondrial Targeting"]
    candesartan["candesartan"] -->|"inhibits"| EXTRACELLULAR_VESICLES
    GJA1["GJA1"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXOSOMES["EXOSOMES"] -->|"interacts"| EXTRACELLULAR_VESICLES
    BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"] -->|"interacts"| EXTRACELLULAR_VESICLES
    AKT["AKT"] -->|"regulates"| EXTRACELLULAR_VESICLES
    EXTRACELLULAR_MATRIX["EXTRACELLULAR MATRIX"] -.biomarker for.-> EXTRACELLULAR_VESICLES
    CANCER["CANCER"] -->|"activates"| EXTRACELLULAR_VESICLES

Outgoing (48)

Target	Relation	Type	Str
CHRONIC INFLAMMATION	activates	concept	0.50

Incoming (106)

Source	Relation	Type	Str
Pi3K	interacts_with	pathway	0.50
Pi3K/Akt	interacts_with	pathway	0.50
PERICYTE	interacts_with	concept	0.50
ANGPT1	interacts_with	concept	0.50
Sepsis	interacts_with	disease	0.50
PI3K/AKT PATHWAY	interacts_with	concept	0.50
PERICYTE	associated_with	concept	0.50
PERICYTES	associated_with	concept	0.50
RAB27A	activates	protein	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
Tumor Microenvironment	activates	process	0.50
Fatty Liver	activates	disease	0.50
Autophagy	regulates	process	0.50
GJA1	regulates	gene	0.50
Cardiovascular	associated_with	disease	0.50
Sod1	activates	gene	0.50
amyotrophic lateral sclerosis	activates	gene	0.50
COMPLEMENT	activates	pathway	0.50
Sod1	associated_with	gene	0.50
Stem Cell	associated_with	cell_type	0.50
Autophagy	activates	process	0.50
PARKINSON	activates	gene	0.50
Parkinson's Disease	activates	disease	0.50
disease	activates	disease	0.50
PARKINSON'S	activates	concept	0.50
DOPAMINE	activates	concept	0.50
PARKINSON	interacts_with	gene	0.50
PARKINSON'S	interacts_with	concept	0.50
Cellular Senescence	associated_with	cell_type	0.50
STEM CELLS	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
TUMOR	associated_with	disease	0.50
MICRORNAS	associated_with	gene	0.50
MIRNAS	associated_with	gene	0.50
EXOSOMES	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
MYELIN	inhibits	concept	0.50
MITOCHONDRIA	activates	cell_type	0.50
Tdp-43	associated_with	pathway	0.50
IMMUNE RESPONSE	activates	pathway	0.50
NEURONS	activates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
STEM CELLS	activates	concept	0.50
Microbiota	associated_with	process	0.50
Gut Microbiota	associated_with	process	0.50
inflammation	activates	pathway	0.50
oxidative stress	activates	phenotype	0.50
Proteins	interacts_with	protein	0.50
AMYLOID-BETA	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (4)

Scientific analyses that reference this entity

Which tau propagation mechanism predominates in different brain regions and dise

neurodegeneration | 2026-04-07 | 0 hypotheses

Trans-synaptic tau spreading and propagation mechanisms in AD

neuroscience | 2026-04-04 | 0 hypotheses

Extracellular vesicle biomarkers for early AD detection

neurodegeneration | 2026-04-02 | 2 hypotheses Top: 0.490

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EXTRACELLULAR VESICLES

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Corticobasal Syndrome (CBS)

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Therapeutics

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Oligodendrocytes

Tau Spreading Mechanism

Mitophagy Pathway in Neurodegeneration

Prion vs Tau/Alpha-Synuclein Propagation: Mechanistic Comparison

Blood-Brain Barrier Biology and Crossing Strategies

substantia-nigra

blood-brain-barrier

Synaptic Vesicle Trafficking in Parkinson's Disease