Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Motor Symptoms: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | associated_with | disease | 0.90 |
| dual task vocal output | modulates | phenotype | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Rotenone | causes | compound | 0.92 |
| Motor Neuron Degeneration | causes | process | 0.90 |
| Nigrostriatal Dopaminergic Neurons | involved_in | cell_type | 0.90 |
| Vinpocetine | protects_against | drug | 0.90 |
| 38934394 | reduces | paper | 0.90 |
| Proteinopathies | causes | disease | 0.85 |
| Microbial Metabolites | associated_with | compound | 0.85 |
| Butyrate | associated_with | biomarker | 0.70 |
| Subthalamic nucleus | regulates | brain_region | 0.70 |
| gut symptoms | risk_factor_for | phenotype | 0.70 |
| intestinal dysbiosis | activates | process | 0.70 |
| retrograde axonal transport | precedes | process | 0.70 |
| 37415197 | likely explained by | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Multi-Clock Ensemble Discordance as a Parkinson's Disease Pr | 0.323 | - | Epigenetic clocks as biomarkers for Alzh |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 4 hypotheses Top: 0.630
neuroscience | 2026-04-10 | 5 hypotheses Top: 0.724
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.924
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Cell-Free DNA and Mitochondria in Parkinson's Disease. [PMID:41373767] | Wojtkowska, Ambrosius | International journal of molec | 2025 | 0 |
| Cell-Free DNA and Mitochondria in Parkinson's Disease. [PMID:41373767] | Unknown | International journal of molec | 2025 | 0 |
| DNA Damage and Parkinson's Disease. [PMID:38673772] | ["Pfeifer Gerd P"] | International journal of molec | 2024 | 0 |
| DNA Damage and Parkinson's Disease. [PMID:38673772] | ["Pfeifer Gerd P"] | International journal of molec | 2024 | 0 |
| Genetic Architecture of Parkinson's Disease. [PMID:37076287] | Shadrina MI, Slominsky PA | Biochemistry (Mosc) | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | Ghosh P, Saadat A | Neurologia (Engl Ed) | 2023 | 0 |
| Neurodegeneration and epigenetics: A review. [PMID:37344098] | ["Ghosh P", "Saadat A"] | Neurologia | 2023 | 0 |
| N6-methyladenosine and Neurological Diseases. [PMID:35032318] | Zhang N, Ding C, Zuo Y | Mol Neurobiol | 2022 | 0 |
| Parkinson's disease treatment: past, present, and future. [PMID:32172471] | Elsworth JD | J Neural Transm (Vienna) | 2020 | 0 |
| Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease. [PMID:28251677] | Giannoccaro, La Morgia, Rizzo, Carelli | Movement disorders : official | 2017 | 0 |
| Epigenetics in Parkinson's Disease. [PMID:28523556] | Pavlou MAS, Outeiro TF | Adv Exp Med Biol | 2017 | 0 |
| Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease. [PMID:28251677] | Unknown | Movement disorders : official | 2017 | 0 |
| Epigenetics in Parkinson's Disease. [PMID:28523556] | ["Pavlou Maria Angeliki S", "Outeiro Tia | Advances in experimental medic | 2017 | 0 |
| Mitochondrial dysfunction and oxidative stress in Parkinson's disease. [PMID:23643800] | ["Subramaniam, Sudhakar Raja", "Chessele | Progress in neurobiology | 2013 | 0 |
| Mitochondrial dysfunction and oxidative stress in Parkinson's disease. [PMID:23643800] | ["Subramaniam, Sudhakar Raja", "Chessele | Progress in neurobiology | 2013 | 0 |
| Mitochondrial DNA and Parkinson's disease. [PMID:1904141] | Unknown | Neurology | 1991 | 0 |
| Mitochondrial DNA and Parkinson's disease. [PMID:1904141] | Di Monte | Neurology | 1991 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.60 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 0.50 · 2026-04-26
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.65 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-01
Hypotheses and analyses mentioning Motor Symptoms in their description or question text
No additional research found