concept

ROTENONE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROTENONE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

42Outgoing

2Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ROTENONE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ROTENONE["ROTENONE"]
    ROTENONE -->|"causes"| Parkinson_Disease["Parkinson Disease"]
    ROTENONE -->|"causes"| Parkinson_s_Disease["Parkinson's Disease"]
    ROTENONE -->|"upregulates"| Ros["Ros"]
    ROTENONE -->|"downregulates"| TH["TH"]
    ROTENONE -->|"causes"| Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
    ROTENONE -->|"upregulates"| ROS["ROS"]
    ROTENONE -->|"causes"| SH_SY5Y_Dopamine_Neurons["SH-SY5Y Dopamine Neurons"]
    ROTENONE -->|"suppresses"| SH_SY5Y["SH-SY5Y"]
    Nac["Nac"] -.protects against.-> ROTENONE

Outgoing (42)

Target	Relation	Type	Str
Parkinson Disease	causes	disease	0.95
Ros	upregulates	process	0.95
TH	downregulates	gene	0.95
SH-SY5Y Dopamine Neurons	causes	cell_type	0.95
SH-SY5Y	suppresses	cell_type	0.95
Mitochondrial Complex I	inhibits	enzyme	0.95
Sh-Sy5Y Dopamine Neuron	suppresses	cell_type	0.95
Parkinson's Disease	causes	disease	0.95
Mitochondrial Dysfunction	causes	process	0.95
ROS	upregulates	process	0.95
PARKINSON'S DISEASE	causes	disease	0.95
MITOCHONDRIA	inhibits	cell_type	0.95
Motor Symptoms	causes	phenotype	0.92
Dopamine Neuron Loss	causes	phenotype	0.90
GPX4	downregulates	gene	0.90
SLC7A11	downregulates	gene	0.90
NCOA4	upregulates	gene	0.90
BCL2	downregulates	gene	0.90
BAX	upregulates	gene	0.90
CASP3	upregulates	gene	0.90
Oxidative Stress	upregulates	process	0.90
Neuroinflammation	causes	process	0.90
Parkinson'S Disease	causes	disease	0.90
COX2	upregulates	gene	0.90
Autophagy	upregulates	process	0.90
Apoptosis	promotes	process	0.90
MICROGLIA	activates	cell_type	0.90
ASTROCYTES	activates	cell_type	0.90
NEURON	causes	cell_type	0.90
NEURODEGENERATION	causes	process	0.90
Motor Dysfunction	causes	phenotype	0.90
oxidative stress	causes	process	0.90
SNCA	upregulates	gene	0.85
IL6	upregulates	gene	0.85
TNF	upregulates	gene	0.85
MTOR	downregulates	gene	0.85
Parkinson-Like Symptoms	causes	phenotype	0.85
Dopamine Neuron	causes	cell_type	0.85
Gut Dysbiosis	causes	process	0.80
Airway Injury	causes	phenotype	0.80
Parkinson's disease	associated_with	disease	0.70
Parkinson's disease	induces	disease	0.70

Incoming (2)

Source	Relation	Type	Str
Nac	protects_against	compound	0.90
vinpocetine	protects_against	drug	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ROTENONE

Understanding Entity Pages

Wiki Pages (20)

Parkinson's Disease

Parthanatos in Neurodegeneration

NRF2 Oxidative Stress Pathway

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Mitophagy Pathway in Neurodegeneration

dendritic-spines

Vitamin D Signaling Pathway in Neurodegeneration

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

substantia-nigra

Mitochondrial Dysfunction in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

Synucleinopathies

NACET (N-Acetylcysteine Ethyl Ester)

Insulin Signaling in Parkinson's Disease