Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NAM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Source | Relation | Type | Str |
|---|---|---|---|
| TREM2 | expressed_in | protein | 0.76 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind | 0.674 | neuroimmunology | What is the temporal sequence of TREM2 s |
| Metabolic NAD+ Salvage Pathway Enhancement Through NAMPT Ove | 0.592 | neurodegeneration | Epigenetic reprogramming in aging neuron |
| Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio | 0.486 | translational neuroscience | Which metabolic biomarkers can distingui |
| Lipid Droplet Dynamics as Phenotype Switches | 0.463 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.435 | translational neuroscience | Which metabolic biomarkers can distingui |
| Lysosomal Positioning Dynamics Modulation | 0.430 | neurodegeneration | Autophagy-lysosome pathway convergence a |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.606
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-10 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propag [PMID:39233232] | Bayati A, McPherson PS | J Biol Chem | 2024 | 1 |
| Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM17 [PMID:37390818] | Zhang J, Zeng W, Han Y, Lee WR, Liou J, | Mol Cell | 2023 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| Endosomal-Lysosomal and Autophagy Pathway in Alzheimer's Disease: A Systematic R [PMID:35754279] | Saffire H Krance, Che-Yuan Wu, Alison C | Journal of Alzheimer's disease | 2022 | 1 |
| Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal stor [PMID:33111641] | Zhang X, Wei M, Fan J, Yan W, Zha X, Son | Autophagy | 2021 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy. [PMID:16973206] | Eskelinen EL | Mol Aspects Med | 2006 | 1 |
| Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration a [PMID:41546868] | ["Tabor G", "Litvinchuk A", "Chen Y", "A | Cell reports | 2026 | 0 |
| Efficacy of Der f 2/Zen 1-LAMP1 Plasmid-Based Vaccine Immunotherapy in Dogs With [PMID:41287364] | Bizikova P, Matsumoto C, Ogino S, Tsukui | Vet Dermatol | 2026 | 0 |
| Measuring lysosome damage and lysophagy in vivo. [PMID:41485143] | Wu Z, Zhan H, Huang Z, Wang C, Li B et a | Autophagy | 2026 | 0 |
| Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198] | Xiao F, Tan X, He A, Zhou Y, Xu K et al. | Autophagy | 2026 | 0 |
| Preparation of a polyclonal antibody against Lysosome-Associated Membrane Protei [PMID:41825675] | Luo J, Shi Y, Jiang X, Zhang B, Chen Y e | Int J Biol Macromol | 2026 | 0 |
| Increased Glycogenin-Exposed Residual Glycogen in Lysosomes Is the Early Patholo [PMID:41923452] | Shi Y, Zhang N, Sun H, Wang Y, Zhao D et | Muscle Nerve | 2026 | 0 |
| Depalmitoylation of TEAD1 facilitates lipid droplet accumulation and resistance [PMID:40889725] | ["Sun X", "Xu S", "Ni Y", "Chen R", "Dai | Free radical biology & medicin | 2025 | 0 |
| Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling i [PMID:41256540] | ["Elbatreek M", "Li Z", "Yu X", "Gehred | bioRxiv : the preprint server | 2025 | 0 |
| AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and d [PMID:39675352] | ["Pierre L", "Juszczak F", "Delmotte V", | Autophagy | 2025 | 0 |
| Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inh [PMID:40375180] | ["Zeng Y", "Guo R", "Chen S", "Lin Y", " | Molecular medicine (Cambridge, | 2025 | 0 |
| Alterations in mRNA level of proteins related to redox state and mitochondria in [PMID:39529534] | Żulińska S, Wencel PL, Czubowicz K, Stro | Folia Neuropathol | 2024 | 0 |
| Lipid droplets in Zika neuroinfection: Potential targets for intervention? [PMID:37820117] | ["Dias S", "Cunha-Fernandes T", "Soares | Memorias do Instituto Oswaldo | 2023 | 0 |