concept

NASH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NASH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

18Outgoing

41Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NASH
Key Genes/Proteins	SLC7A11, MIZ1, DRAK2, TREM2, JNK
Related Diseases	HCC, APOPTOSIS, INFLAMMATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NASH["NASH"]
    NASH -->|"causes"| Hepatocellular_Carcinoma["Hepatocellular Carcinoma"]
    NASH -->|"causes"| KUPFFER_CELLS["KUPFFER_CELLS"]
    NASH -->|"causes"| HCC["HCC"]
    NASH -->|"activates"| TREM2["TREM2"]
    NASH -->|"activates"| CD9["CD9"]
    NASH -->|"inhibits"| VASCULAR_SIGNALING["VASCULAR_SIGNALING"]
    lipophagy["lipophagy"] -.protects against.-> NASH
    SLC7A11["SLC7A11"] -.protects against.-> NASH
    MIZ1["MIZ1"] -.prevents.-> NASH
    mitophagy["mitophagy"] -.protects against.-> NASH

Outgoing (19)

Target	Relation	Type	Str
KUPFFER_CELLS	causes	cell_type	0.72
HCC	causes	disease	0.72
APOPTOSIS	interacts_with	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
JNK	activates	gene	0.65
TREM2	causes	gene	0.65
MACROPHAGE	causes	cell_type	0.65
MACROPHAGE	activates	cell_type	0.65
CIRRHOSIS	interacts_with	disease	0.65
TREM2	activates	gene	0.64
CD9	activates	gene	0.64
oxidative_stress	associated_with	phenotype	0.64
inflammation	associated_with	phenotype	0.64
VASCULAR_SIGNALING	inhibits	pathway	0.60
OXIDATIVE STRESS	expressed_in	phenotype	0.55
MACROPHAGE	implicated_in	cell_type	0.55
JNK	associated_with	gene	0.45
TNF	associated_with	gene	0.45

Incoming (41)

Source	Relation	Type	Str
lipophagy	protects_against	process	0.90
SLC7A11	protects_against	gene	0.90
MIZ1	prevents	protein	0.90
DRAK2	aggravates	gene	0.90
mitophagy	protects_against	process	0.85
NAM	associated_with	cell_type	0.72
TREM2	associated_with	protein	0.68
HEPATOCELLULAR CARCINOMA	interacts_with	disease	0.65
SLC7A11	regulates	gene	0.65
SLC7A11	treats	gene	0.65
SLC7A11	activates	gene	0.65
MACROPHAGES	activates	cell_type	0.65
TNF	causes	gene	0.65
SLC7A11	inhibits	gene	0.64
STAT3	expressed_in	gene	0.55
SLC7A11	expressed_in	gene	0.55
STING	associated_with	gene	0.45
STAT3	associated_with	gene	0.45
JAK2	associated_with	gene	0.45
HEPATOCYTES	associated_with	cell_type	0.45
CTNNB1	associated_with	gene	0.45
TP53	associated_with	gene	0.45
TERT	associated_with	gene	0.45
SLC7A11	associated_with	gene	0.45
AMPK	associated_with	gene	0.45
RAPAMYCIN	associated_with	drug	0.45
SQSTM1	associated_with	gene	0.45
SIRT1	associated_with	gene	0.45
SIRT3	associated_with	gene	0.45
BECN1	associated_with	gene	0.45
LAMP2	associated_with	gene	0.45
FOXO1	associated_with	gene	0.45
PPARA	associated_with	gene	0.45
KDM6B	associated_with	gene	0.45
MTOR	associated_with	gene	0.45
TFEB	associated_with	gene	0.45
ULK1	associated_with	gene	0.45
CREB	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
TLR4	associated_with	gene	0.45
TLR9	associated_with	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NASH

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Growth Factor Therapeutics: Investment Landscape Analysis

GPT - Alanine Transaminase (ALT)

Liver-Brain Neurodegeneration Axis

Peptidream Inc.

can-fite-biopharma

RGS10 Gene

CIDEA — Cell Death-Inducing DFFA-Like Effector A

Farnesoid X Receptor (FXR) Signaling in Neurodegeneration

Lipophagy Activation Therapy for Neurodegeneration

CD9

Adenosine A3 Receptor Neurons

PSD-95 (Postsynaptic Density Protein 95)

TGR5 Agonist Therapy

Howard Hughes Medical Institute (HHMI)

PPAR Agonists for Neurodegeneration

Kupffer Cells

MAP3K5 — Mitogen-Activated Protein Kinase Kinase Kinase 5