gene

NCF4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NCF4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ncf4

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🧬 Gene Info

Gene Symbol	NCF4
Full Name	Neutrophil Cytosolic Factor 4 (p40^phox^)
Protein Type	Enzyme
Function	is a regulatory subunit of the NADPH oxidase (NOX2) complex that plays a critical role in generating reactive oxygen species (ROS) in phagocytic cells.
Primary Expression	microglia—the resident immune cells of the brain—where it contributes to neuroinflammatory processes that are central to neurodegenerative disease pat
Amino Acids	80 aa
UniProt ID	Q9UHI5
NCBI Gene ID	3074
Ensembl ID	ENSG00000100129
OMIM	604467
GeneCards	NCF4
Human Protein Atlas	NCF4
PX Domain (1-80 aa)	Phosphoinositide-binding module that targets p40^phox^ to cellular membranes and phagocytic vesicles
SH3 Domain (120-180 aa)	Proline-rich region that mediates protein-protein interactions with other phox components
PCD Domain (200-280 aa)	Protein interaction domain
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCF4 — AlphaFold Q9UHI5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NCF4 (Neutrophil Cytosolic Factor 4)

gene · 2227 words

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Pathway Diagram

graph TD
    NCF4["NCF4"]
    neurodegeneration["neurodegeneration"]
    NCF4 -->|"implicated_in"| neurodegeneration
    style NCF4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity