gene

NCOA2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NCOA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

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🧬 Gene Info

Gene Symbol	NCOA2
Function	NCOA2 is a ~175 kDa protein containing multiple functional domains that mediate protein-protein interactions:
Primary Expression	both neurons and glial cells, with particular enrichment in pyramidal neurons and Purkinje cells [@ncoa2003]
Subcellular Localization	Primarily nuclear, consistent with its role as a transcriptional coactivator.
Molecular Weight	175 kDa
Ensembl ID	ENSG00000140396
GeneCards	NCOA2
Human Protein Atlas	NCOA2
N-terminal Domain	Contains basic helix-loop-helix (bHLH) and PAS (PER-ARNT-SIM) domains that mediate dimerization and DNA binding [@xu1999].
C-terminal Activating Domains	Three autonomous activation domains (AD1, AD2, AD3) that recruit coactivators including histone acetyltransferases (CBP/p300), histone methyltransferases, and the Mediator complex [@leo2000].
LXXLL Motifs	Seven LXXLL motifs that facilitate binding to nuclear receptor AF-2 domains in a ligand-dependent manner [@mckenna2002].
Estrogen Receptors (ERα, ERβ)	Critical for neuroprotection, mitochondrial function, and cognitive function [@brinton2008].
Glucocorticoid Receptor (GR)	Regulates stress response and neuronal viability [@sapolsky1996].
Thyroid Hormone Receptors (TRα, TRβ)	Essential for brain development and myelin maintenance [@bernal2000].
Retinoid X Receptors (RXR)	Partners in nuclear receptor heterodimers that regulate gene networks involved in neuronal survival [@mangelsdorf1995].
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

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Canonical Page

NCOA2 Gene

gene · 1141 words

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Pathway Diagram

graph TD
    NCOA2["NCOA2"]
    neurodegeneration["neurodegeneration"]
    NCOA2 -->|"implicated_in"| neurodegeneration
    style NCOA2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning NCOA2 in their description or question text

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