Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFAF2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NDUFAF2 |
| Full Name | NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 2 |
| Chromosome | 5q31.1. |
| Protein Family | Complex I assembly factor family |
| Function | ND1 Subunit Incorporation: The protein assists in the proper insertion and folding of MT-ND1, the mitochondrial-encoded core subunit of Complex I |
| Subcellular Localization | Mitochondrial matrix |
| Molecular Weight | 20 kDa |
| Amino Acids | 182 aa |
| UniProt ID | [Q9H0U4](https://www.uniprot.org/uniprot/Q9H0U4) |
| GeneCards | NDUFAF2 |
| Human Protein Atlas | NDUFAF2 |
| Early assembly factors | NDUFAF1, NDUFAF3, and NDUFAF4 act during the earliest stages |
| ND1 module assembly | NDUFAF2 functions specifically at this stage, along with other factors |
| Late assembly | Additional factors complete the holoenzyme |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFAF2["NDUFAF2"]
neurodegeneration["neurodegeneration"]
NDUFAF2 -->|"implicated_in"| neurodegeneration
style NDUFAF2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity