Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NDUFAF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NDUFAF3 - NADH Dehydrogenase Complex Assembly Factor 3 - role in mitochondrial complex I assembly and neurodegenerative diseases
| Gene Symbol | NDUFAF3 |
| Full Name | NADH Dehydrogenase Complex Assembly Factor 3 |
| Chromosome | 3p21.31 |
| Function | encodes a critical mitochondrial assembly factor required for the proper assembly and function of complex I (NADH:ubiquinone oxidoreductase) of the mitochondrial electron transport chain[@saada2009... |
| Primary Expression | High in brain, heart, muscle (high energy tissues) |
| Molecular Weight | 22 kDa |
| Amino Acids | 198 aa |
| UniProt ID | [Q9P0U4](https://www.uniprot.org/uniprot/Q9P0U4) |
| Ensembl ID | ENSG00000163293 |
| OMIM | 618196 |
| GeneCards | NDUFAF3 |
| Human Protein Atlas | NDUFAF3 |
| Associated Diseases | neurodegeneration |
| KG Connections | 5 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NDUFAF3["<b>NDUFAF3</b>"]
ERBB3["ERBB3"]
NDUFAF3 -->|"associated with"| ERBB3
RHOH["RHOH"]
NDUFAF3 -->|"associated with"| RHOH
CDK10["CDK10"]
NDUFAF3 -->|"associated with"| CDK10
MC1R["MC1R"]
NDUFAF3 -->|"associated with"| MC1R
neurodegeneration["neurodegeneration"]
NDUFAF3 -->|"implicated in"| neurodegeneration
GTPBP3["GTPBP3"]
GTPBP3 -->|"associated with"| NDUFAF3
style NDUFAF3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| GTPBP3 | associated_with | gene | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||