entity

NMDA receptors

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NMDA receptors: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

2Analyses

3Outgoing

6Incoming

0Experiments

19Debates

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Outgoing (3)

Target	Relation	Type	Str
calcium toxicity	causes	phenotype	0.90
Amyloid-beta-induced synaptic depression	mediates	phenotype	0.70
synaptic depression	causes (NMDA receptors mediate synaptic depression in amyl)	mechanism	0.45

Incoming (6)

Source	Relation	Type	Str
37369776	mediate	paper	0.90
37369776	regulate	paper	0.90
APOE	activates	gene	0.70
APOE4	enhances	gene	0.70
APOE	enhances	gene	0.70
PTK2B	modulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms explain how KCNJ2 inhibition mitigates TBI-induced neu

neurodegeneration | 2026-04-13 | 0 hypotheses

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 73 hypotheses Top: 0.968

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (19)

Multi-agent debates referencing this entity

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

closed · Rounds: 6 · Score: 0.95 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

closed · Rounds: 4 · Score: 0.65 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

closed · Rounds: 4 · Score: 0.71 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

closed · Rounds: 4 · Score: 0.87 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

closed · Rounds: 4 · Score: 0.48 · 2026-04-27

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

closed · Rounds: 4 · Score: 0.54 · 2026-04-27

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

closed · Rounds: 4 · Score: 0.19 · 2026-04-27

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Hypothesis debate: Closed-loop transcranial focused ultrasound to restore hippoc

closed · Rounds: 4 · Score: 0.50 · 2026-04-27

Related Research

Hypotheses and analyses mentioning NMDA receptors in their description or question text

No additional research found