Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NMDAR2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NMDAR2B |
| Function | The NMDA receptor subunit NR2B (GRIN2B gene product) is a modulatory subunit that combines with NR1 to form functional NMDA receptors. |
| Subcellular Localization | Plasma membrane, postsynaptic density |
| Molecular Weight | 166 kDa |
| UniProt ID | Q13224 |
| GeneCards | NMDAR2B |
| Human Protein Atlas | NMDAR2B |
| Associated Diseases | neuropathic pain |
| Interactions | PKA |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NMDAR2B["NMDAR2B"]
PKA["PKA"]
NMDAR2B -->|"activates"| PKA
neuropathic_pain["neuropathic pain"]
NMDAR2B ==>|"causes"| neuropathic_pain
neurodegeneration["neurodegeneration"]
NMDAR2B -->|"implicated in"| neurodegeneration
style NMDAR2B fill:#1a237e,stroke:#4fc3f7,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| neuropathic pain | causes | phenotype | 0.90 |
| PKA | activates | protein | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||