Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | NOL3 |
| Chromosome | 16q22.1 |
| Protein Type | Gene |
| Function | ARC also inhibits the intrinsic mitochondrial pathway by interacting with Bax and preventing its translocation to mitochondria 2. |
| Primary Expression | neurons and protects against excitotoxicity, oxidative stress, and mitochondrial dysfunction |
| Amino Acids | 219 aa |
| UniProt ID | Q9HC36 |
| NCBI Gene ID | 64124 |
| Ensembl ID | ENSG00000164124 |
| GeneCards | NOL3 |
| Human Protein Atlas | NOL3 |
| [Amyloid-Beta](/proteins/amyloid-beta) | Aβ treatment downregulates NOL3 expression in neurons, creating a vicious cycle of increased vulnerability |
| [Tau](/proteins/tau) | Phosphorylated tau accumulation is associated with reduced ARC-mediated neuroprotection |
| APOE4 | The APOE4 allele may exacerbate NOL3 downregulation, contributing to increased AD risk |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NOL3["NOL3"]
neurodegeneration["neurodegeneration"]
NOL3 -->|"implicated_in"| neurodegeneration
style NOL3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NOL3 in their description or question text
No additional research found