| Gene Symbol | NOL3 |
| Chromosome | 16q22.1 |
| Protein Type | Gene |
| Function | ARC also inhibits the intrinsic mitochondrial pathway by interacting with Bax and preventing its translocation to mitochondria 2. |
| Primary Expression | neurons and protects against excitotoxicity, oxidative stress, and mitochondrial dysfunction |
| Amino Acids | 219 aa |
| UniProt ID | Q9HC36 |
| NCBI Gene ID | 64124 |
| Ensembl ID | ENSG00000164124 |
| GeneCards | NOL3 |
| Human Protein Atlas | NOL3 |
| [Amyloid-Beta](/proteins/amyloid-beta) | Aβ treatment downregulates NOL3 expression in neurons, creating a vicious cycle of increased vulnerability |
| [Tau](/proteins/tau) | Phosphorylated tau accumulation is associated with reduced ARC-mediated neuroprotection |
| APOE4 | The APOE4 allele may exacerbate NOL3 downregulation, contributing to increased AD risk |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
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