protein

NOXO1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NOXO1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for NOXO1 Protein

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🔬 Protein Info

Gene Symbol	NOXO1
Full Name	NADPH Oxidase Organizer 1
Function	is a protein encoded by the NOXO1 gene that ### NOX1 Complex Organization
Molecular Weight	41.1 kDa
Amino Acids	366 aa
UniProt ID	[Q8NFA2](https://www.uniprot.org/uniprotkb/Q8NFA2)
GeneCards	NOXO1
Human Protein Atlas	NOXO1
Proline-rich regions	Mediate binding to NOXA1
PB1 domain	Similar to p47phox but constitutively active
Oxidative stress	NOXO1/NOX1 contributes to AD oxidative damage
[Tau](/proteins/tau) phosphorylation	ROS from NOX1 affects kinase/phosphatase balance
Dopaminergic vulnerability	ROS from NOX1 may damage dopaminergic neurons
Neuroinflammation	Contributes to microglial ROS production
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NOXO1 Protein

protein · 753 words

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NOXO1 Gene

gene · 724 words

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Pathway Diagram

graph TD
    NOXO1["NOXO1"]
    neurodegeneration["neurodegeneration"]
    NOXO1 -->|"implicated_in"| neurodegeneration
    style NOXO1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NOXO1 in their description or question text

No additional research found