gene

NPAS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for NPAS1 - Neuronal PAS Domain Protein 1

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	NPAS1
Full Name	Neuronal PAS Domain Protein 1
Aliases	Page for NPAS1
Chromosome	19q13.12
Protein Type	Transcription Factor
Function	encodes a neuronal transcription factor of the bHLH-PAS (basic Helix-Loop-Helix-Per-ARNT-Sim) family, involved in circadian rhythm regulation, brain development, and cellular stress responses.
Primary Expression	motor neurons and may regulate genes important for their survival
GeneCards	NPAS1
Human Protein Atlas	NPAS1
bHLH Domain	Basic helix-loop-helix DNA-binding domain that recognizes E-box sequences (CANNTG) in gene promoters [@ponti2000]
PAS Domains	Two PAS domains (PAS-A and PAS-B) that mediate protein-protein interactions with other transcription factors and sense environmental signals [@gu2000]
Transactivation Domain	C-terminal domain that recruits transcriptional co-activators and the basal transcription machinery
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NPAS1 - Neuronal PAS Domain Protein 1

gene · 1091 words

→

Pathway Diagram

graph TD
    NPAS1["NPAS1"]
    neurodegeneration["neurodegeneration"]
    NPAS1 -->|"implicated_in"| neurodegeneration
    style NPAS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPAS1 in their description or question text

No additional research found