| Gene Symbol | NPAS1 |
| Full Name | Neuronal PAS Domain Protein 1 |
| Aliases | Page for NPAS1 |
| Chromosome | 19q13.12 |
| Protein Type | Transcription Factor |
| Function | encodes a neuronal transcription factor of the bHLH-PAS (basic Helix-Loop-Helix-Per-ARNT-Sim) family, involved in circadian rhythm regulation, brain development, and cellular stress responses. |
| Primary Expression | motor neurons and may regulate genes important for their survival |
| GeneCards | NPAS1 |
| Human Protein Atlas | NPAS1 |
| bHLH Domain | Basic helix-loop-helix DNA-binding domain that recognizes E-box sequences (CANNTG) in gene promoters [@ponti2000] |
| PAS Domains | Two PAS domains (PAS-A and PAS-B) that mediate protein-protein interactions with other transcription factors and sense environmental signals [@gu2000] |
| Transactivation Domain | C-terminal domain that recruits transcriptional co-activators and the basal transcription machinery |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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