Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NPR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NPR1 (NPR-A, GC-A) |
| Full Name | Natriuretic Peptide Receptor 1 / Guanylate Cyclase 1 |
| Chromosome | 1q22 |
| Protein Family | Natriuretic peptide receptors (NPR1, NPR2/NPR-B, NPR3/NPR-C) |
| Protein Type | Receptor |
| Function | NPR1-mediated cGMP production regulates multiple downstream effectors |
| Primary Expression | multiple brain regions: |
| Amino Acids | 1057 aa |
| UniProt ID | P16066 |
| NCBI Gene ID | 4880 |
| Ensembl ID | ENSG00000118445 |
| OMIM | 108012 |
| Extracellular ligand-binding domain | N-terminal region that binds natriuretic peptides (ANP, BNP, CNP) with different affinities |
| Transmembrane domain | Single α-helix that anchors the receptor in the plasma membrane |
| Kinase-like domain | Intracellular domain with ATP-binding activity that regulates the guanylate cyclase domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NPR1["NPR1"]
neurodegeneration["neurodegeneration"]
NPR1 -->|"implicated_in"| neurodegeneration
style NPR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NPR1 in their description or question text
No additional research found