gene

NRP2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NRP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	NRP2
Function	NRP2 participates in multiple signaling pathways:
GeneCards	NRP2
Human Protein Atlas	NRP2
Axon Guidance	NRP2 serves as a receptor for class 3 semaphorins (SEMA3B, SEMA3F), directing axon migration
Dendritic Morphogenesis	Regulates dendritic arborization
Synapse Formation	Involved in inhibitory synapse development
Neural Crest Cell Migration	Critical for peripheral nervous system development
Angiogenesis	NRP2 acts as VEGF receptor, supporting blood vessel formation
Lymphangiogenesis	Particularly important for lymphatic vessel development
Vascular Patterning	Guides developing blood and lymphatic vessels
Substantia Nigra	Dopaminergic neurons
Peripheral Nervous System	Enteric neurons, sensory ganglia
Endothelial Cells	Lymphatic and vascular endothelium
Neural Crest Derivatives	Schwann cells, melanocytes
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NRP2 Gene

gene · 577 words

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Pathway Diagram

graph TD
    NRP2["NRP2 Receptor"]
    SEMA3F["SEMA3F Ligand"]
    PLXNA3["PLXNA3 Co-receptor"]
    VEGF["VEGF Signaling"]
    AXON_GUIDANCE["Axon Guidance"]
    REPULSION["Growth Cone Collapse"]
    ANGIOGENESIS["Angiogenesis"]
    NEURONAL_DEATH["Neuronal Death"]
    BBB["Blood-Brain Barrier"]
    INFLAMMATION["Neuroinflammation"]
    ALZHEIMERS["Alzheimer Disease"]
    STROKE["Ischemic Stroke"]
    NEUROPROTECTION["Neuroprotection"]
    PI3K_AKT["PI3K/AKT Pathway"]
    
    SEMA3F -->|"binds"| NRP2
    NRP2 -->|"co-receptor with"| PLXNA3
    SEMA3F -->|"activates"| REPULSION
    NRP2 -->|"mediates"| AXON_GUIDANCE
    NRP2 -->|"binds VEGF"| ANGIOGENESIS
    VEGF -->|"activates"| PI3K_AKT
    PI3K_AKT -->|"promotes"| NEUROPROTECTION
    REPULSION -->|"contributes to"| NEURONAL_DEATH
    ANGIOGENESIS -->|"maintains"| BBB
    BBB -->|"dysfunction leads to"| INFLAMMATION
    INFLAMMATION -->|"promotes"| NEURONAL_DEATH
    NEURONAL_DEATH -->|"characteristic of"| ALZHEIMERS
    NRP2 -->|"dysregulated in"| STROKE
    STROKE -->|"causes"| NEURONAL_DEATH
    
    style NRP2 fill:#1a3a4a,stroke:#4fc3f7
    style NEUROPROTECTION fill:#1a3a2a,stroke:#81c784
    style PI3K_AKT fill:#1a3a2a,stroke:#81c784
    style ANGIOGENESIS fill:#1a3a2a,stroke:#81c784
    style NEURONAL_DEATH fill:#3a1a1a,stroke:#ef5350
    style INFLAMMATION fill:#3a1a1a,stroke:#ef5350
    style REPULSION fill:#3a1a1a,stroke:#ef5350
    style SEMA3F fill:#2a1a3a,stroke:#ce93d8
    style PLXNA3 fill:#2a1a3a,stroke:#ce93d8
    style ALZHEIMERS fill:#3a2a1a,stroke:#ffa726
    style STROKE fill:#3a2a1a,stroke:#ffa726

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NRP2 in their description or question text

No additional research found