protein

NRP2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NRP2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

A single-pass transmembrane domain anchors NRP2 in the plasma membrane and positions the extracellular and intracellular domains appropriately for ligand binding and signal transduction.

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🔬 Protein Info

Gene Symbol	NRP2PROTEIN
Protein Type	Receptor
Function	is a transmembrane co-receptor protein that plays essential roles in development and adult physiology by mediating interactions between cells and their microenvironment.
Subcellular Localization	** \| Plasma membrane, cytoplasm, endosomes \|
Molecular Weight	110 kDa
Amino Acids	40 aa
GeneCards	NRP2PROTEIN
Human Protein Atlas	NRP2PROTEIN
Mammalian Notch Homology Domain (c)	This region mediates interactions with other receptors, particularly in the context of VEGF receptor co-receptor function. The c domain also plays a role in NRP2 self-association.
PDZ Domain Binding Motif	The C-terminal PDZ binding motif (SEA) allows NRP2 to interact with PDZ domain-containing scaffold proteins including NRP1-associated molecules, enabling formation of signaling complexes.
Serine/Threonine Residues	Potential phosphorylation sites regulate protein interactions and signaling.
Axon Collateral Formation	Beyond initial guidance, NRP2 signaling influences the formation of axon collaterals and synaptic connections.
Circuit Assembly	By precisely controlling axon targeting, NRP2 contributes to the establishment of functional neural circuits including those in the limbic system, visual cortex, and spinal cord.
VEGF-C/VEGF-D Signaling	NRP2 forms complexes with VEGF receptor 2 (VEGFR2) and enhances VEGF-C and VEGF-D signaling, promoting lymphatic endothelial cell proliferation and lymphatic vessel formation.
Angiogenesis	NRP2 also modulates blood vessel formation through interactions with VEGF-A and other VEGFs.
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

nrp2-protein

protein · 1687 words

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Pathway Diagram

graph TD
    NRP2PROTEIN["NRP2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    NRP2PROTEIN -->|"implicated_in"| neurodegeneration
    style NRP2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

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Debates (0)

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Related Research

Hypotheses and analyses mentioning NRP2PROTEIN in their description or question text

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