Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NT5C2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NT5C2 |
| Chromosome | 10q24.31 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 65 kDa |
| Amino Acids | 572 aa |
| Exons | 19 |
| GeneCards | NT5C2 |
| Human Protein Atlas | NT5C2 |
| Active site | Contains the signature HD domain (His-Asp) for metal-dependent hydrolase activity |
| Allosteric site | Features an allosteric binding site for ATP and other nucleotides |
| Dimeric organization | Functions as a homodimer |
| Substrate specificity | Broad specificity for IMP, AMP, GMP, CMP, and other nucleoside monophosphates |
| Metal requirement | Requires Mg2+ or Mn2+ for catalytic activity |
| Purine Recycling | Catalyzes IMP + H2O → Inosine + Phosphate, enabling nucleoside salvage |
| Nucleotide Homeostasis | Maintains intracellular nucleotide pools for DNA/RNA synthesis |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NT5C2["NT5C2"]
neurodegeneration["neurodegeneration"]
NT5C2 -->|"implicated_in"| neurodegeneration
style NT5C2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NT5C2 in their description or question text
No additional research found