| Gene Symbol | NT5C2 |
| Chromosome | 10q24.31 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 65 kDa |
| Amino Acids | 572 aa |
| Exons | 19 |
| GeneCards | NT5C2 |
| Human Protein Atlas | NT5C2 |
| Active site | Contains the signature HD domain (His-Asp) for metal-dependent hydrolase activity |
| Allosteric site | Features an allosteric binding site for ATP and other nucleotides |
| Dimeric organization | Functions as a homodimer |
| Substrate specificity | Broad specificity for IMP, AMP, GMP, CMP, and other nucleoside monophosphates |
| Metal requirement | Requires Mg2+ or Mn2+ for catalytic activity |
| Purine Recycling | Catalyzes IMP + H2O → Inosine + Phosphate, enabling nucleoside salvage |
| Nucleotide Homeostasis | Maintains intracellular nucleotide pools for DNA/RNA synthesis |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!