Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ntkr2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Gene Symbol | NTKR2 |
| Protein Type | Receptor |
| Function | NTRK2 encodes TrkB (Tropomyosin receptor kinase B), the primary receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). |
| Primary Expression | both the developing and adult nervous system, where it supports neuronal survival, process outgrowth, synapse formation, and plasticity |
| Ensembl ID | ENSG00000157184 |
| GeneCards | NTKR2 |
| Human Protein Atlas | NTKR2 |
| Associated Diseases | depression: |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
A["Regulatory elements"] --> B["ntkr2 gene"]
B --> C["mRNA transcript"]
C --> D["Protein product"]
D --> E["Cellular function"]
E --> F["Disease relevance"]
B --> G["Variant effects"]
G --> F
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
class B gene
class D protein| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR2 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:NTKR2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||