| Gene Symbol | NTKR2 |
| Protein Type | Receptor |
| Function | NTRK2 encodes TrkB (Tropomyosin receptor kinase B), the primary receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). |
| Primary Expression | both the developing and adult nervous system, where it supports neuronal survival, process outgrowth, synapse formation, and plasticity |
| Ensembl ID | ENSG00000157184 |
| GeneCards | NTKR2 |
| Human Protein Atlas | NTKR2 |
| PLC-γ Pathway | Phospholipase C-gamma activation leads to IP3/DAG signaling and calcium release. This pathway regulates synaptic plasticity and gene expression |
| PI3K/Akt Pathway | Promotes cell survival through Akt phosphorylation, inhibiting pro-apoptotic proteins. Critical for neuronal survival |
| RAS/MAPK Pathway | Regulates gene expression, cell differentiation, synaptic plasticity, and long-term memory formation |
| cAMP/PKA Pathway | Modulates ion channel function and gene transcription |
| Long-term Potentiation (LTP) | BDNF release during high-frequency stimulation activates TrkB, enhancing glutamate receptor function and spine growth |
| Long-term Depression (LTD) | TrkB signaling also contributes to LTD, depending on the context and receptor isoform |
| Synaptic Strength | TrkB activation modulates the strength of both excitatory and inhibitory synapses |
| Spine Morphogenesis | TrkB signaling promotes the formation and maintenance of dendritic spines |
| Associated Diseases | depression: |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |