protein

NUP58PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NUP58PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Nucleoporin 58 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

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🔬 Protein Info

Gene Symbol	NUP58PROTEIN
Protein Type	Channel
Function	is a crucial component of the nuclear pore complex (NPC) central channel.
Subcellular Localization	</strong></td><td>Nuclear envelope, Nuclear pore complex</td></tr>
Molecular Weight	58 kDa
Amino Acids	483 aa
GeneCards	NUP58PROTEIN
Human Protein Atlas	NUP58PROTEIN
N-terminal coiled-coil domain	Mediates dimerization with NUP54, forming the structural core of the central channel
Central FG repeat region	Contains phenylalanine-glycine (FG) repeat motifs that create the selective permeability barrier
C-terminal domain	Contributes to nuclear basket association and regulatory interactions
NUP58-NUP54 Heterodimer	Forms a stable coiled-coil dimer essential for central channel structure
FG Repeat Motifs	~20 FG repeats create a meshwork that allows selective transport
Asymmetric Distribution	NUP58 is preferentially located on the nuclear side of the NPC
Phosphorylation Sites	Regulated by kinases including CDK1 during cell cycle
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nucleoporin 58

protein · 1172 words

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Pathway Diagram

graph TD
    NUP58PROTEIN["NUP58PROTEIN"]
    neurodegeneration["neurodegeneration"]
    NUP58PROTEIN -->|"implicated_in"| neurodegeneration
    style NUP58PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

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Related Research

Hypotheses and analyses mentioning NUP58PROTEIN in their description or question text

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